Liver protein associated with type 2 diabetes in older adults

Jul 08, 2008

The presence of a protein expressed by the liver which inhibits insulin action may identify individuals more likely to develop type 2 diabetes, according to a new study led by a researcher from the UCSD School of Medicine, to be published July 9 in the Journal of the American Medical Association (JAMA.)

Researchers led by Joachim H. Ix, M.D., M.A.S., assistant professor in the Division of Nephrology and Hypertension and the Division of Preventive Medicine at UC San Diego and at the San Diego Veterans Affairs Healthcare System, found that higher serum levels of a protein called fetuin-A, produced by liver cells, was associated with type 2 diabetes in humans, independent of other risk factors.

"Higher fetuin-A was associated with a 1.7-fold increased risk of diabetes, when adjusted for other factors," said Ix. Despite compelling laboratory and animal data of the protein's role in insulin resistance, until now the association of fetuin-A with new development of type 2 diabetes had not been evaluated in humans, according to Ix. "On the basis of this study, fetuin-A might be considered as a novel therapeutic target for prevention or treatment of insulin resistance,' he said.

Type 2 diabetes is a metabolic disorder characterized by insulin resistance that has become a global epidemic. The increased prevalence of obesity is a major contributing factor; however diabetes does not develop in all obese individuals, and reasons why one individual develops type 2 diabetes while another dose not are largely unknown.

Recent research shows that proteins from fat tissue called adipocytokines regulate the metabolism of blood sugar or glucose, and may ultimately prove to be a target for new diabetes therapies. In contrast, fetuin-A is produced in liver cells, and is secreted into blood. In laboratory studies, fetuin-A binds to the insulin receptor found in muscle and fat, resulting in insulin resistance – the hallmark of diabetes. Preliminary data from a separate study of participants without diabetes had shown an association between fetuin-A and insulin resistance.

In this study, the researchers measured levels of fetuin-A in 519 diabetes-free individuals aged 70 to 79 years, and followed them for development of diabetes for six years. Participants with the highest levels of fetuin-A showed a higher risk of developing diabetes, when compared to those with low levels. The association was not affected by levels of adipocytokines.

"The associations we demonstrate are independent of an individual's level of physical activity, the presence of inflammation or other common measures of insulin resistance," said Ix. "The results were also similar in participants, regardless of gender, race or obesity status."

The researchers also state that further studies should evaluate whether the results prove true in middle-aged individuals in whom the incidence rate of type 2 diabetes is highest.

Source: University of California - San Diego

Explore further: US cautiously optimistic after no new Ebola in 5 days

add to favorites email to friend print save as pdf

Related Stories

US company sells out of Ebola toys

7 hours ago

They might look tasteless, but satisfied customers dub them cute and adorable. Ebola-themed toys have proved such a hit that one US-based company has sold out.

UN biodiversity meet commits to double funding

7 hours ago

A UN conference on preserving the earth's dwindling resources wrapped up Friday with governments making a firm commitment to double biodiversity aid to developing countries by 2015.

Facebook unfriends federal drug agency

8 hours ago

(AP)—Facebook wants assurances from the Drug Enforcement Administration that it's not operating any more fake profile pages as part of ongoing investigations.

Partial solar eclipse over the U.S. on Thursday, Oct. 23

8 hours ago

People in most of the continental United States will be in the shadow of the Moon on Thursday afternoon, Oct. 23, as a partial solar eclipse sweeps across the Earth. For people looking through sun-safe filters, from Los Angeles, ...

Recommended for you

US cautiously optimistic after no new Ebola in 5 days

1 hour ago

With no new Ebola cases in five days, US authorities were cautious but hopeful Monday that the virus has been contained in the United States after a flawed response revealed shortcomings in the system.

Nigeria declared Ebola-free in 'spectacular success'

1 hour ago

Nigeria was declared Ebola-free on Monday in a "spectacular success" in the battle to contain the spread of a virus which is devastating Guinea, Sierra Leone and Liberia where more than 4,500 people have died.

EU says 'increased' effort needed to tackle Ebola

2 hours ago

European Union foreign ministers agreed Monday to step up efforts to contain Ebola to prevent it becoming a global threat, including ensuring proper care for international health workers.

User comments : 0