New treatment approach promising for lymphoma patients in the developing world

Jul 06, 2008

Preliminary results suggest that patients with aggressive non-Hodgkin's lymphoma in the developing world might benefit from a modified chemotherapy regimen, researchers say.

At the ESMO Conference Lugano (ECLU) organized by the European Society for Medical Oncology, a group headed by Prof. Hamdy Azim from Cairo University reports that giving these patients chemotherapy every 2 weeks, rather than every 3 weeks as usual, improved treatment outcomes.

The standard regimen in this case is called CHOP (chemotherapy regime), which is given every 3 weeks. In the developed world, CHOP is administered in combination with an antibody therapy called rituximab.

But many patients in developing countries, including Egypt where this study was conducted, cannot afford this treatment, so they are offered CHOP alone.

"We hypothesized that if CHOP or a CHOP-like regimen was given every two weeks instead of three, a superior outcome could be achieved," says Dr. Hatem A. Azim Jr, who presented these results at ECLU.

To see if this was the case, they analyzed five trials that compared CHOP to regimens given every two weeks. Using two statistical analyses, they showed that regimens every two weeks had superior response rate, disease-free and overall survival; however in one method, the response rate analysis did not reach statistical significance.

"We believe that this work could provide good evidence to support the use of the 2-weekly regimen," Dr. Azim Jr said. One issue that remains to be assessed is how well patients tolerate the more intense treatment, he noted.

"Patients on the 2-weekly regimens have to receive injections with 'growth factors' to ensure that severe toxicities to the white blood cells do not occur," he said. "Even so, the cost of these injections per cycle is much lower than that of rituximab. The preliminary results are encouraging in providing patients who cannot afford the cost of rituximab, a better alternative than CHOP."

Source: European Society for Medical Oncology

Explore further: Syria hit by flesh-eating maggot disease

add to favorites email to friend print save as pdf

Related Stories

Homeopathy prospers even as controversy rages

Mar 11, 2011

A popular homeopathic flu remedy boasts that it comes with no side effects, no drug interactions and won't make you drowsy. But the product also lacks something most people expect to find in their medicine: active ingredients.

Translating Chinese medicine for the West

Oct 11, 2010

In a traditional Chinese medicine store in central Beijing, part of the Tongrentang chain founded 342 years ago, three white-coated workers follow traditions that stretch even further back in time. They sort and chop an exotic ...

Being a control freak aids dividing cells

Jul 28, 2008

Micromanagers may generate resentment in an office setting, but they get results in your body. New data indicate that a dividing cell takes micromanagement to the extreme, tagging more than 14,000 different sites on its proteins ...

Recommended for you

Syria hit by flesh-eating maggot disease

4 hours ago

Three cases of myiasis have been reported near Damascus, marking the first appearance of the flesh-eating maggot disease in Syria, UN health experts said Friday.

Brazil's Amazon region houses latex 'love factory'

5 hours ago

Deep in Amazonia, Raimundo Pereira expertly cuts a gash in a rubber tree to collect white sap destined for the nearby factory at Xapuri, the world's only producer of contraceptives made from tropical forest latex.

Ebola scare boosts business for US company

5 hours ago

The Ebola scare has subsided in the United States, at least temporarily, but an Alabama manufacturer is still trying to catch up with a glut of orders for gear to protect against the disease.

Sperm can carry Ebola for 82 days: WHO

5 hours ago

Sperm can carry the Ebola virus for at least 82 days, the World Health Organization said Friday, urging men recovering from the disease to use condoms for three months after the onset of symptoms.

'Chatty' cells help build the brain

9 hours ago

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.