Scientists fix bugs in our understanding of evolution

Jun 19, 2008
Sequence Alignment
Caption: Sequence alignment according to the new, phylogeny-aware method. Credit: Nick Goldman, EMBL-EBI

[B]A new computational tool allows the most accurate insights into evolution ever[/B]
What makes a human different from a chimp? Researchers from the European Molecular Biology Laboratory's European Bioinformatics Institute [EMBL-EBI] have come one important step closer to answering such evolutionary questions correctly. In the current issue of Science they uncover systematic errors in existing methods that compare genetic sequences of different species to learn about their evolutionary relationships.

They present a new computational tool that avoids these errors and provides accurate insights into the evolution of DNA and protein sequences. The results challenge our understanding of how evolution happens and suggest that sequence turnover is much more common than assumed.

"Evolution is happening so slowly that we cannot study it by simply watching it. That's why we learn about the relationships between species and the course and mechanism of evolution by comparing genetic sequences," says Nick Goldman, group leader at EMBL-EBI.

The four letter code that constitutes the DNA of all living things changes over time; for example individual or several letters can be copied incorrectly [substitution], lost [deletion] or gained [insertion]. Such changes can lead to functional and structural changes in genes and proteins and ultimately to the formation of new species. Reconstructing the history of these mutation events reveals the course of evolution.

A comparison of multiple sequences starts with their alignment. Characters in different sequences that share common ancestry are matched and gains and losses of characters are marked as gaps. Since this procedure is computationally heavy, multiple alignments are often built progressively from several pairwise alignments. It is impossible, however, to judge if a length difference between two sequences is a deletion in one or an insertion in the other sequence. For correct alignment of multiple sequences, distinguishing between these two events is crucial. Existing methods, that fail to do that, lead to a flawed understanding of the course of evolution.

"Our new method gets around these errors by taking into account what we already know about evolutionary relationships," says Ari Löytynoja, who developed the tool in Goldman's lab. "Say we are comparing the DNA of human and chimp and can't tell if a deletion or an insertion happened. To solve this our tool automatically invokes information about the corresponding sequences in closely related species, such as gorilla or macaque. If they show the same gap as the chimp, this suggests an insertion in humans."

Findings achieved with the new technique suggest that insertions are much more common than assumed, while the frequency of deletions has been overestimated by existing methods. A likely reason for these systematic errors of other techniques is that they were originally developed for structural matching of protein sequences. The focus of molecular biology is shifting, however, and understanding functional changes in genomes requires specifically designed methods that consider sequences' histories. Such approaches will likely reveal further bugs in our understanding of evolution in future and might challenge the conventional picture of sequence evolution.

Source: European Molecular Biology Laboratory

Explore further: Will rapprochement mean new research collaborations between Cuba and the U.S.?

add to favorites email to friend print save as pdf

Related Stories

DNA sheds light on why largest lemurs disappeared

Dec 16, 2014

Ancient DNA extracted from the bones and teeth of giant lemurs that lived thousands of years ago in Madagascar may help explain why the giant lemurs went extinct. It also explains what factors make some surviving ...

Big-data analysis reveals gene sharing in mice

Dec 16, 2014

Rice University scientists have detected at least three instances of cross-species mating that likely influenced the evolutionary paths of "old world" mice, two in recent times and one in the distant past.

Habitual use of fire as told from cave near Haifa

Dec 15, 2014

Scientists have not been content with the exercise of dating when man first used fire. While the earliest evidence for hominin use of fire dates to more than a million years ago, scientists have been keen ...

Plants with pocket-sized genomes

Dec 12, 2014

Members of Genlisea, a genus of carnivorous plants, possess the smallest genomes known in plants. To elucidate genomic evolution in the group as a whole, researchers have now surveyed a wider range of species, ...

Genes tell story of birdsong and human speech

Dec 11, 2014

His office is filled with all sorts of bird books, but Duke neuroscientist Erich Jarvis didn't become an expert on the avian family tree because of any particular interest in our feathered friends. Rather, ...

Recommended for you

Study: Alcatraz inmates could have survived escape

Dec 17, 2014

The three prisoners who escaped from Alcatraz in one of the most famous and elaborate prison breaks in U.S. history could have survived and made it to land, scientists concluded in a recent study.

User comments : 8

Adjust slider to filter visible comments by rank

Display comments: newest first

quantum_flux
4 / 5 (4) Jun 19, 2008
This is very exciting, this should have tremendous benefits as far as genetic engineering and gene therapy are concerned....not to mention putting an end to YEC once and for all (but that latter one is obviously of trivial importance though, memes will be memes and YEC may be either replaced with New Age crap or with the new and improved bruised turd "lying through the teeth theology" of Francis Collins and that thought makes me every bit as sick as ID does). Can't people just read Carl Sagan's book "The Pale Blue Dot"?

http://irrational...-do.html
superhuman
4.7 / 5 (3) Jun 19, 2008
Its not fixing any "bugs" the improvement is possible because the number of known sequences for various species is steadily increasing and not because there was an error in previous methodology.

It wont benefit genetic engineering or gene therapy instead it will allow better calculation of evolutionary distance between species.
DGBEACH
5 / 5 (1) Jun 19, 2008
I agree with superhuman, any perceptible changes would take hundreds or thousands of years to notice, and all they will show will be a constant distance between the species.
aussiecarter
not rated yet Jun 20, 2008
The experience gained in genome sequencing is amazing. With increased data capture and mining there should be some very interesting articles and evoluation of thinking.
mabarker
1 / 5 (5) Jun 20, 2008
This is directed at the vitriol of 'quantum flugz'. Evidently she didn't read the above article carefully - she's too busy Christian-bashing (very intolerant).
"The results challenge our understanding of how evolution happens . . . " - and this is why darwinism is a fact, right QF?
"Evolution is happening so slowly that we cannot study it by simply watching it." This flies in the face of all the creation-bashers who have insisted in years past that evolution CAN be observed (anemic examples such a Drosophila, antibiotic-resistant bacteria & darwin's finches are then listed).
"Reconstructing the history of these mutation events reveals the course of evolution." Yes - showing that genomes are going downhill - fast. Mutations are building up leading to genetic entropy. For every supposed "beneficial" mutation, there are a million bad ones (Gerrish & Lenski 1998). The actual rate of 'beneficial mutations' is small as to thwart any measurement (Bataillon 2000, Elena et al 1998). Esentially all 'beneficial mutations' (do they ever happen?) are un-selectable. So quantum flugz' god - natural selection - could never favor any such 'beneficial mutations' - and they would all drift out of the population. See Kimura's work - he preferred not to represent the distribution of the ethreal "favorable" mutations.
I like what atheist Ehrlich said (2000) on p. 21 of his book, "Because mutations are random relative to need and because organisms generally fit well into their environments, mutations normally are either neutral or harmful; only very rarely are they helpful - just as a random change made by poking a screwdriver into the guts of your computer will rarely improve its performance."
Go ahead and put your faith in that analogy, QF!
D666
4.3 / 5 (3) Jun 20, 2008
To mabarker:

So, you believe that putting quotes around every 3rd phrase constitutes a rebuttal? I'm pretty sure you intended to defend creationism, based on your first two paragraphs, but the post is a complete failure. Sarcasm by way of quoting, snide asides in parentheses, and random quotations don't constitute a rebuttal, *especially* when the quotations don't actually contradict evolution. And that's assuming they're honest quotations and not Gould-isms.

Also, just as an aside, a theist chiding a non-theist for "intolerance" has got to be the ultimate hypocracy. As I was writing this, I tried to come up with any identifiable group that is more intolerant in general than theists, and I came up empty. So spare us the crocodile tears.

nano999
not rated yet Jun 20, 2008
mabarker - what are you rambling on about?
mabarker
1 / 5 (2) Jun 20, 2008
It's obvious that the people above are not actually reading this page about secularists vain attempt to 'fix bugs' regarding the philosophy of neo-darwinism.
De 666 whines about my delivery (I'm so surprised she finds my post "a complete failure" with a name like hers) otherwise ignoring the fantasy of "beneficial mutations". Even IF they could occur - they are unable to remain in a population. The strong predominance of deleterious mutations (redundant) absolutely guarantees a net loss of genetic information. That's why, as a biologist, I subscribe to the concept of genetic entropy.
I shudder to think most darwinists believe mutations would be a bell-shaped distribution with good mutations one one side and deleterious ones on the other. The correct distribution would be close to Kimura's (1979) with "beneficial" mutations falling within his "no-selection zone". Kimura was famous for showing that most mutations are nearly-neutral, and therefore are not subject to selection (the god of the darwinist). This makes progressive evolution (synthetic theory), on the genomic level, virtually impossible (see Ehrlich's quote).
The above article is shot through with "suggest" "assume" "overestimated" "likely".Has anyone bothered to read the last sentence (or any) of the article? Such is the status of molecular evolution and the illusion of precision (see Graur & Martin, Trends in Genetics, Feb. '04).
In regard to intolerance 666, your reverting to the pouty-lipped "Well, you do it to" is the juvenile response I expected. I was simply saying in my first post that instead of discussing the article 'quantum' decided to denegrate people of faith. That is an intolerant position.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.