Fat mass and obesity assoicated genes increased risk of disease in Mexican-Americans

Jun 10, 2008

A study from the University of Southern California suggests people of Mexican-American descent who have genetic variants of fat gene FTO and Arachidonate 5-Lipoxygenase (5-LO) had higher triglyceride and lower HDL levels. The findings were presented as an oral presentation on Sunday, June 8, at the American Diabetes Association 68th Scientific Sessions held in San Francisco.

"Our results confirm the association between FTO and fat mass and indicate that the 5-LO promoter modifies the association between FTO and lipid levels," says Mary Helen Black, candidate for PhD in Statistical Genetics and Genetic Epidemiology, at the Keck School of Medicine of USC and lead author of the study. "The genetic interaction between 5-LO and FTO was significantly associated with an inverse relationship between triglycerides and HDL levels."

The study examined 1286 participants from 165 Mexican American family members of a proband with a history of gestational diabetes and 107 control trios from the BetaGene study. Results suggest subjects who have the FTO rs9939609 A allele and at least one 5-LO short repeat allele had a 26 percent higher triglyceride count and 8 percent lower HDL cholesterol levels compared to participants with the FTO TT genotype. In contrast, among participants with two 5-LO long repeat alleles, those with an FTO A allele showed very little change in triglycerides or HDL compared to those with the FTO TT genotype.

"Understanding the interaction between these genes may help us understand the mechanism by which FTO affects adiposity. Because obesity and dyslipidemia are often precursors to diabetes, these gene interactions may play a vital role in future drug target development, which is another step toward advancing personalized medicine," Black says.

Source: University of Southern California

Explore further: Interleukin-27: Can a cytokine with both pro and anti-inflammatory activity make a good drug target?

add to favorites email to friend print save as pdf

Related Stories

US company sells out of Ebola toys

6 hours ago

They might look tasteless, but satisfied customers dub them cute and adorable. Ebola-themed toys have proved such a hit that one US-based company has sold out.

UN biodiversity meet commits to double funding

6 hours ago

A UN conference on preserving the earth's dwindling resources wrapped up Friday with governments making a firm commitment to double biodiversity aid to developing countries by 2015.

Partial solar eclipse over the U.S. on Thursday, Oct. 23

7 hours ago

People in most of the continental United States will be in the shadow of the Moon on Thursday afternoon, Oct. 23, as a partial solar eclipse sweeps across the Earth. For people looking through sun-safe filters, from Los Angeles, ...

Recommended for you

Team untangles the biological effects of blue light

9 hours ago

Blue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania's School of Medicine and School of Arts and Sciences have teased apart the ...

Mouse model provides new insight in to preeclampsia

10 hours ago

Worldwide, preeclampsia is a leading cause of maternal deaths and preterm births. This serious pregnancy complication results in extremely high blood pressure and organ damage. The onset of preeclampsia is associated with ...

User comments : 0