Fat mass and obesity assoicated genes increased risk of disease in Mexican-Americans

Jun 10, 2008

A study from the University of Southern California suggests people of Mexican-American descent who have genetic variants of fat gene FTO and Arachidonate 5-Lipoxygenase (5-LO) had higher triglyceride and lower HDL levels. The findings were presented as an oral presentation on Sunday, June 8, at the American Diabetes Association 68th Scientific Sessions held in San Francisco.

"Our results confirm the association between FTO and fat mass and indicate that the 5-LO promoter modifies the association between FTO and lipid levels," says Mary Helen Black, candidate for PhD in Statistical Genetics and Genetic Epidemiology, at the Keck School of Medicine of USC and lead author of the study. "The genetic interaction between 5-LO and FTO was significantly associated with an inverse relationship between triglycerides and HDL levels."

The study examined 1286 participants from 165 Mexican American family members of a proband with a history of gestational diabetes and 107 control trios from the BetaGene study. Results suggest subjects who have the FTO rs9939609 A allele and at least one 5-LO short repeat allele had a 26 percent higher triglyceride count and 8 percent lower HDL cholesterol levels compared to participants with the FTO TT genotype. In contrast, among participants with two 5-LO long repeat alleles, those with an FTO A allele showed very little change in triglycerides or HDL compared to those with the FTO TT genotype.

"Understanding the interaction between these genes may help us understand the mechanism by which FTO affects adiposity. Because obesity and dyslipidemia are often precursors to diabetes, these gene interactions may play a vital role in future drug target development, which is another step toward advancing personalized medicine," Black says.

Source: University of Southern California

Explore further: Retinal regeneration in zebrafish (w/ Video)

add to favorites email to friend print save as pdf

Related Stories

Social Security spent $300M on 'IT boondoggle'

5 hours ago

(AP)—Six years ago the Social Security Administration embarked on an aggressive plan to replace outdated computer systems overwhelmed by a growing flood of disability claims.

Cheaper wireless plans cut into AT&T 2Q profit

5 hours ago

(AP)—AT&T posted lower net income for the latest quarter due to cheaper cellphone plans it introduced as a response to aggressive pricing from smaller competitor T-Mobile US.

Awarded a Pell Grant? Better double-check

5 hours ago

(AP)—Potentially tens of thousands of students awarded a Pell Grant or other need-based federal aid for the coming school year could find it taken away because of a mistake in filling out the form.

Recommended for you

Diet affects men's and women's gut microbes differently

22 hours ago

The microbes living in the guts of males and females react differently to diet, even when the diets are identical, according to a study by scientists from The University of Texas at Austin and six other institutions published ...

User comments : 0