Fat mass and obesity assoicated genes increased risk of disease in Mexican-Americans

Jun 10, 2008

A study from the University of Southern California suggests people of Mexican-American descent who have genetic variants of fat gene FTO and Arachidonate 5-Lipoxygenase (5-LO) had higher triglyceride and lower HDL levels. The findings were presented as an oral presentation on Sunday, June 8, at the American Diabetes Association 68th Scientific Sessions held in San Francisco.

"Our results confirm the association between FTO and fat mass and indicate that the 5-LO promoter modifies the association between FTO and lipid levels," says Mary Helen Black, candidate for PhD in Statistical Genetics and Genetic Epidemiology, at the Keck School of Medicine of USC and lead author of the study. "The genetic interaction between 5-LO and FTO was significantly associated with an inverse relationship between triglycerides and HDL levels."

The study examined 1286 participants from 165 Mexican American family members of a proband with a history of gestational diabetes and 107 control trios from the BetaGene study. Results suggest subjects who have the FTO rs9939609 A allele and at least one 5-LO short repeat allele had a 26 percent higher triglyceride count and 8 percent lower HDL cholesterol levels compared to participants with the FTO TT genotype. In contrast, among participants with two 5-LO long repeat alleles, those with an FTO A allele showed very little change in triglycerides or HDL compared to those with the FTO TT genotype.

"Understanding the interaction between these genes may help us understand the mechanism by which FTO affects adiposity. Because obesity and dyslipidemia are often precursors to diabetes, these gene interactions may play a vital role in future drug target development, which is another step toward advancing personalized medicine," Black says.

Source: University of Southern California

Explore further: Nerve cells and blood vessels in eye 'talk' to prevent disease, study finds

Related Stories

Classroom acoustics for architects

9 hours ago

The Acoustical Society of America (ASA) has published a free online booklet for architects to aid in the application of ANSI/ASA S12.60-2010/Part 1-American National Standard Acoustical Performance Criteria, Design Requirements, ...

Recommended for you

Inaccurate reporting jeopardizing clinical trials

Apr 26, 2015

The team led by Dr Sheena Cruickshank of the Faculty of Life Sciences and Professor Andy Brass from the School of Computer Science analysed 58 papers on research into inflammatory bowel disease published between 2000 and ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.