Potential biomarkers for pancreatic cancer identified

Jun 10, 2008

In a new study in PLoS Medicine, Samir Hanash and colleagues from Fred Hutchinson Cancer Research Center in Seattle report the identification of proteins that appear in increased numbers at an early stage of pancreatic tumor development in a mouse model and may be a useful tool in detecting early tumors in humans.

Using a well-characterized mouse model of pancreatic cancer the researchers identified a panel of five proteins selected on the basis of their increased level at an early stage of tumor development in the mouse and tested them in a blinded study in 26 humans from the CARET (Carotene and Retinol Efficacy Trial) cohort.

The panel of proteins discriminated pancreatic cancer cases from matched controls in blood specimens obtained between 7 and 13 months prior to the development of symptoms and clinical diagnosis of pancreatic cancer.

Although further validation will be needed, these results indicate that mouse models of cancer, in combination with in-depth proteomic analysis, could help identify candidate markers in human cancer and potentially be used for early detection, say the researchers.

Citation: Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, et al. (2008) A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med 5(6): e123.-- medicine.plosjournals.org/perl… journal.pmed.0050123

Source: Public Library of Science

Explore further: Survival differences seen for advanced-stage laryngeal cancer

add to favorites email to friend print save as pdf

Related Stories

Treating vascular disorders with a cell-based strategy

Oct 18, 2012

A research team at Weill Cornell Medical College has discovered a way to utilize diagnostic prenatal amniocentesis cells, reprogramming them into abundant and stable endothelial cells capable of regenerating damaged blood ...

Science denied: Why does doubt persist?

Oct 12, 2012

The sign in front of the tall display case at the Smithsonian Institution's Museum of Natural History lures visitors to "meet one of your oldest relatives." Inside stands a morganucodon, a mouse-like animal ...

Recommended for you

Survival differences seen for advanced-stage laryngeal cancer

Nov 27, 2014

The five-year survival rate for advanced-stage laryngeal cancer was higher than national levels in a small study at a single academic center performing a high rate of surgical therapy, including a total laryngectomy (removal ...

Gene test aids cancer profile

Nov 27, 2014

The first round of chemotherapy did little to suppress Ron Bose's leukemia. The second round, with 10 times the dose, knocked the proliferating blast cells down, but only by half.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.