Circadian math: 1 plus 1 doesn't always equal 2

Jun 07, 2008
Circadian math: 1 plus 1 doesn't always equal 2
Researchers have found that the circadian system may be able to distinguish between lights of different colors. Credit: Rensselaer/Lighting Research Center

Like a wristwatch that needs to be wound daily for accurate time-telling, the human circadian system — the biological cycles that repeat approximately every 24 hours — requires daily light exposure to the eye's retina to remain synchronized with the solar day. In a new study published in the June issue of Neuroscience Letters, researchers have demonstrated that when it comes to the circadian system, not all light exposure is created equal.

The findings have profound implications for exploring how lighting can be used to adjust our bodies' clocks, and they could redefine the way lighting is manufactured, according to Mariana Figueiro, lead author of the paper and assistant professor in the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute.

Short-wavelength light, including natural light from the blue sky, is highly effective at stimulating the circadian system. Exposure to other wavelengths — and thus colors — of light may necessitate longer exposure times or require higher exposure levels to be as effective at "winding the watch."

In some instances, exposure to multiple wavelengths (colors) of light simultaneously can result in less total stimulation to the circadian system than would result if either color were viewed separately, a phenomenon known as "spectral opponency." The LRC scientists have shown that the circadian system shares neurons in the retina — which exhibit spectral opponency and form the foundation for our perception of color — with the visual system. Thus, in principle, the circadian system may be able to distinguish between lights of different colors.

More than meets the eye

To demonstrate that the circadian system exhibited spectral opponency formed in the retina, the researchers exposed 10 subjects to three experimental conditions: one unit of blue light to the left eye plus one unit of green light to the right eye; one unit of blue light to the right eye plus one unit of green light to the left eye; and half a unit of blue light plus half a unit of green light to both eyes and then measured each individual's melatonin levels, a natural indicator of the circadian clock.

"The first two conditions — exposure to a single color in each eye — did not result in a significant difference in melatonin suppression, while the third condition — exposure to both colors in both eyes — resulted in significantly less melatonin suppression," said Figueiro. "Even though the amount of light at the eye was the same in all three conditions, when the two colors of light were combined in the same eye, the response of the system was reduced due to spectral opponent mechanisms formed in the retina."

This indicates that spectral opponency is a fundamental characteristic of how the human retina converts light into neural signals in the human circadian system, according to Figueiro.

The findings also verify the accuracy of a new quantification system LRC researchers developed in 2006 to calculate the "circadian efficacy" of different light sources. Called the model of human circadian phototransduction,
the tool correctly predicted the circadian system response demonstrated under each of the three experimental conditions.

The model appears to correctly predict the circadian response to any light source, and can be used as the foundation for a new system of circadian photometry, much like the current system of photometry based on human vision.

Quantification of light as a stimulus for the circadian system provide new scientific insights into how the human body processes light for the circadian system, according to Figueiro.

Nocturnal melatonin, a hormone produced at night and under conditions of darkness, is used as a marker for the circadian clock. Scientific evidence suggests that disruption of the circadian system — and thus the melatonin cycle — may result in increased malignant tumor growth, as well as poor sleep quality, lack of alertness, seasonal depression, and immune deficiencies.

Now that the model can predict circadian efficacy for any light source, Figueiro and her research partners have begun studying the way time of night affects the potency of light exposure. Once complete, the comprehensive model will allow manufacturers to develop light sources that most effectively stimulate and, importantly, do not stimulate the circadian system.

Source: Rensselaer Polytechnic Institute

Explore further: Novel marker discovered for stem cells derived from human umbilical cord blood

add to favorites email to friend print save as pdf

Related Stories

Chrono, the last piece of the circadian clock puzzle?

18 hours ago

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep ...

Honda smart home offers vision for zero carbon living

Mar 26, 2014

Honda and the University of California, Davis, today marked the opening of Honda Smart Home US, showcasing technologies that enable zero net energy living and transportation. The home in UC Davis West Village ...

Vibrations influence the circadian clock of a fruit fly

Jan 31, 2014

The internal circadian clock of a Drosophila (fruit fly) can be synchronised using vibrations, according to research published today in the journal Science. The results suggest that an animal's own moveme ...

Does lighting pollution poses risk?

Sep 11, 2012

A panel of world experts discussed "Light Pollution and its Ecophysiological Consequences" and shed light on the extent of the dangers and harm that night-time artificial lighting causes, emphasizing that it is the short ...

Circadian clocks in a blind fish

Sep 06, 2011

Do animals that have evolved for millions of years underground, completely isolated from the day-night cycle, still "know" what time it is? Does a normal circadian clock persist during evolution under constant darkness? A ...

Recommended for you

Leeches help save woman's ear after pit bull mauling

6 minutes ago

(HealthDay)—A pit bull attack in July 2013 left a 19-year-old woman with her left ear ripped from her head, leaving an open wound. After preserving the ear, the surgical team started with a reconnection ...

New pain relief targets discovered

11 hours ago

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching ...

Building 'smart' cell-based therapies

12 hours ago

A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other ...

User comments : 5

Adjust slider to filter visible comments by rank

Display comments: newest first

superhuman
not rated yet Jun 07, 2008
So exposure to blue light resembling the sky should suppress sleepiness while white light does not. I'm going to test it If I can get a proper blue light somewhere.
HenisDov
4 / 5 (1) Jun 08, 2008
Origin Of Circadian Rhythm

For Archaic Genes Sunlight Was The Only Source Of Energy

A. Posted Nov 25 2007 in physorg forum
and e-mailed to Editor-in-Chief, Journal of Circadian Rhythms 28 Nov 2007

Circadian Rhythm and Plant Genes Fuel-Up

(1) One of the routes, of the mechanisms of energy absorption, by which some archaegenes became and function as active energy packages, i.e. became living organisms:

http://www.physor...032.html

(2) My elsewhere note on the Origin of Circadian Rhythm applies neatly in Plant Genes Fuel-Up, too. Both these processes fit in with comprehension that genes-genomes are living organisms.

(3) Genome observed "Oscillating" in coordination with circadian rhythm:

http://www.physor...572.html

But circadian rhythm may be innate gene-genome characteristic, inborn/brought-about at the energetic conditions during the genesis of genes in the process of phasing from chemical olygomer to replicating life, to genes, to base life energy packages .....

See

http://blog.360.y...Q--?cq=1&p=372

Chapter I, G. Life's Drive and Purpose

"1. If one accepts, intuitively and logically, Pasteur's observation that all life must come from previously existing life, then the answer to "what makes a mono- and poly-cell life-form a Life" is the answer to "what makes some molecular associations in cells LIVES", and vice versa. It is the "lifehood" of genes that makes us and all other forms of life on Earth living organisms, and evolution has been the route of Life's ever more complexing progress since the first replication of the first gene."

B. Posted 12 Jan 2008 in physorg forum

It occurs to me that the point of the above post has not been duly obvious, i.e. that it has not clearly explained the source of Earth's organism's Circadian Rhythm.

I therefore wish to add this to the original post, the emphasis that for the archaic genes, parents of all Earth's Life, direct sunlight was the ONLY source of energy. Hence circadian rhythm is most certainly an innate gene-genome characteristic.

Dov Henis

x646d63
3 / 5 (2) Jun 08, 2008
I remember reading that a yogi once went 300 days without food and claimed that he got his energy from staring at the sun for 45 minutes as it rose in the morning...maybe we still have the ability to generate energy from sunlight...
AgentMarty
not rated yet Jun 09, 2008
I bet it was a blind yogi.
nilbud
not rated yet Aug 05, 2008
Phew, I thought for a second someone was having a go at the Canadians again.

More news stories

Turning off depression in the brain

Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's ...

Scientists tether lionfish to Cayman reefs

Research done by U.S. scientists in the Cayman Islands suggests that native predators can be trained to gobble up invasive lionfish that colonize regional reefs and voraciously prey on juvenile marine creatures.

White House updating online privacy policy

A new Obama administration privacy policy out Friday explains how the government will gather the user data of online visitors to WhiteHouse.gov, mobile apps and social media sites. It also clarifies that ...

Six Nepalese dead, six missing in Everest avalanche

At least six Nepalese climbing guides have been killed and six others are missing after an avalanche struck Mount Everest early Friday in one of the deadliest accidents on the world's highest peak, officials ...