Israeli study finds obstructive sleep apnea is health factor from day 1

May 21, 2008

Obstructive sleep apnea (OSA) in very young children may cause some of the adverse cardiovascular health consequences seen in older children and adults with the condition, according to researchers in Israel, who will present their findings at the American Thoracic Society’s 2008 International Conference in Toronto on Wednesday, May 21.

“OSA starts from the first year of life,” said Aviv Goldbart, M.D., the pediatric pulmonologist and sleep specialist who led the study at Ben-Gurion University’s Soroka Medical Center in Israel, “yet very little is known regarding the cognitive, cardiovascular and other medical consequences.”

The study is the first to look at the relationship between systemic inflammation and cardiovascular morbidity in children with OSA. Researchers assessed 70 young children, ages 12 to 26 months, whose OSA was confirmed by polysomnography. The children were scheduled to undergo adenotonsillectomy (T&A) to remove enlarged tonsils and adenoids. On the morning of their surgery, the children were tested to determine levels of N Terminal pro B type Natriuretic Peptide (NTproBNP), a peptide marker of ventricular strain and C Reactive Protein (CRP), a marker for inflammation.

Compared to matched controls, 46 children with OSA had significantly higher levels of NTproBNP and of CRP. Three months after surgery, 20 children were evaluated. The average levels of NTproBNP and CRP dropped below that of the control group.

“Increased levels of CRP in children with OSA may require cardiovascular assessment,” said Dr. Goldbart. “But further studies are needed first to determine the need to diagnose and treat OSA at a very young age.”

He and his colleagues plan to conduct a follow-up study to determine if abnormal cardiovascular function in these children puts them at greater risk for cardiovascular morbidity as adults.

Source: American Thoracic Society

Explore further: Recorded Ebola deaths top 7,000

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Recorded Ebola deaths top 7,000

7 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

12 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.