Anti-HAV antibodies in beta-thalassemia

Apr 30, 2008

Thalassemic patients were found to present a higher prevalence of anti-HAV IgG antibodies than matched healthy subjects from the same geographic area. This finding is difficult to explain, but it may be attributed to the higher vulnerability of thalassemics to HAV infection and to passive transfer of anti-HAV antibodies by blood transfusion.

This study, performed by a team led by Associate Professor C Labropoulou-Karatza and Dr D Siagris, is described in a research article to be published on March 14, 2008, in the World Journal of Gastroenterology.

In Greece, the lack of Hepatitis A epidemics since the early 1980s and the improvement of socioeconomic and hygienic conditions over the last decade seem to have contributed to a decline in prevalence of anti-HAV antibodies. However, the authors observed that the majority of their beta-thalassemia patients were anti-HAV-IgG-positive.

In the view of the authors, the findings of this study are in contradiction with those of previous studies which showed a lower prevalence of anti-HAV antibodies in thalassemic patients.

In order to further reduce the incidence of liver infections in multitransfused thalassemic patients, the authors recommend active immunization for HAV in that population.

In the view of the reviewers, the strength of this study is surely due to the dimension of the population and the long history of the patients (10 years).

Further research, including testing the prevalence of anti-HAV antibodies in family members of thalassemia patients and in the frozen aliquots of donors¡¯ plasma, would confirm these findings.

Source: World Journal of Gastroenterology

Explore further: Two Michigan high school students develop screening tools to detect lung and heart disease

add to favorites email to friend print save as pdf

Related Stories

Obama unveils new measures to stem identity theft

1 hour ago

US President Barack Obama on Friday ordered "pin and chip" security measures for government payment systems, aiming to stem the proliferation of credit card fraud and identity theft.

Twitpic to shutter service after all

2 hours ago

Twitpic on Friday put out word that the service is shutting down after all, apologizing for a "false alarm" that a merger would be its salvation.

Microsoft CEO launches diversity training effort

3 hours ago

(AP)—Microsoft CEO Satya Nadella has again apologized to employees and announced in a company-wide memo that all workers will receive expanded training on how to foster an inclusive culture as he works to repair damage ...

Recommended for you

Team untangles the biological effects of blue light

12 hours ago

Blue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania's School of Medicine and School of Arts and Sciences have teased apart the ...

Mouse model provides new insight in to preeclampsia

12 hours ago

Worldwide, preeclampsia is a leading cause of maternal deaths and preterm births. This serious pregnancy complication results in extremely high blood pressure and organ damage. The onset of preeclampsia is associated with ...

User comments : 0