MDCT accurate in detecting stenosis in calcified coronary artery plaque

Apr 11, 2008

Multidetector CT angiography can accurately predict the presence of obstructive disease (stenosis) in small and moderate-sized calcified coronary artery plaque (CAP), and is even fairly accurate in diagnosing large and heavily calcified CAP, according to a recent study conducted by researchers at Thomas Jefferson University Hospital in Philadelphia, PA.

The study evaluated 31 patients who had one or more calcified CAP, comparing the results from CCTA to cardiac catheterization. “It is commonly believed that when coronary artery plaque is calcified, (particularly when it is heavily calcified), MDCT is unreliable in determining the degree of stenosis,” said David C. Levin, MD, lead author of the study. However, in this study CCTA and cardiac catheterization were concordant in 58 of 61 small calcified CAPs (95%), 20 of 22 moderate-sized (91%) and 29 of 43 large calcified CAPs (67%). The study showed that overestimation of stenosis occurred in 2 of the small lesions, 2 of the moderate-sized lesions and 14 of the large lesions.

“The results indicate that even when heavily calcified plaque is present, MDCT is pretty accurate in determining how much vessel narrowing it has caused. However, we have to recognize that when large and heavily calcified plaques are seen on MDCT, we tend to overestimate the degree of stenosis that results. This overestimation seems to be unavoidable in many cases,” said Dr. Levin.

Source: American Roentgen Ray Society

Explore further: The dopamine transporter: Researchers study a common link between addiction and neurological disease

add to favorites email to friend print save as pdf

Related Stories

Working group explores the 'frustration' of spin glasses

23 minutes ago

Spin glasses are frustrating. Although the ideas have been around for decades and form the foundation of countless complex systems models, they have nonetheless resisted researchers' efforts to understand exactly how they ...

The goTenna device pitch is No Service, No Problem

1 hour ago

In the new age of Internet-based crowdfunding with special price offers, where startup teams try to push their product closer and closer to the gate of entry, goTenna's campaign offers a most attractive pitch. ...

Scientists enlist big data to guide conservation efforts

2 hours ago

Despite a deluge of new information about the diversity and distribution of plants and animals around the globe, "big data" has yet to make a mark on conservation efforts to preserve the planet's biodiversity. ...

66-yard crater appears in far northern Siberia

3 hours ago

Russian scientists say they believe a 60-meter (66-yard) wide crater discovered recently in far northern Siberia could be the result of changing temperatures in the region.

Recommended for you

Strategy proposed for preventing diseases of aging

11 hours ago

Medicine focuses almost entirely on fighting chronic diseases in a piecemeal fashion as symptoms develop. Instead, more efforts should be directed to promoting interventions that have the potential to prevent ...

User comments : 0