Study finds doxycycline effective against filariasis in Southeast Asia

Apr 09, 2008

Doxycycline alone is more effective against the most common form of filariasis in Southeast Asia than the standard treatment, with significantly fewer side effects, according to a new study published in the May 1 issue of Clinical Infectious Diseases and currently available online.

Approximately 120 million people worldwide are infected with thread-like parasitic filarial worms causing lymphatic filariasis. This tropical disease, found in regions of Asia, Africa, and Central and South America, is spread by mosquitoes and causes episodes of acute and chronic inflammation, including elephantiasis. The standard treatment has been a combination of diethylcarbamazine and albendazole, which are accompanied by significant side effects in about half of the patients, including fever, headache, dizziness, and enlarged lymph nodes.

Doxycycline works by targeting a symbiotic bacterium, Wolbachia, which live inside the filarial worms. When the bacteria are killed by the antibiotic, then the worms also die. Doxycycline has previously been found to be effective against filariasis caused by the Wuchereria species. However, more than half of the filarial cases in Southeast Asia are caused by the Brugia species. Researchers in Indonesia set out to determine whether doxycycline would be effective against this species as well, with fewer adverse reactions than standard treatment.

The authors treated 161 patients with doxycycline plus placebo, diethylcarbamazine and albendazole plus placebo, or both treatments. After 12 months, 77 percent of the patients given doxycycline plus placebo tested negative for the Brugia parasite, compared to just 27 percent of those given diethylcarbamazine and albendazole plus placebo. Those given both treatments fared best: 87.5 percent tested negative for the parasite.

Nearly 43 percent of patients given diethylcarbamazine and albendazole experienced severe adverse reactions including high fevers. None of the patients given doxycycline had severe reactions. Of those receiving both treatments, about 16 percent had severe reactions.

In addition to offering a safer treatment alternative, the authors said the study demonstrates that the symbiotic Wolbachia bacteria in the parasite are a viable target for further anti-filariasis drug discovery.

Source: Infectious Diseases Society of America

Explore further: Lebanon reports first suspected case of Ebola

add to favorites email to friend print save as pdf

Related Stories

And now, the volcano forecast

10 minutes ago

Scientists are using volcanic gases to understand how volcanoes work, and as the basis of a hazard-warning forecast system.

Cheaper silicon means cheaper solar cells

21 minutes ago

Researchers at the Norwegian University of Science and Technology have pioneered a new approach to manufacturing solar cells that requires less silicon and can accommodate silicon with more impurities than ...

Recommended for you

US lawmaker: New case raises questions on Ebola

57 minutes ago

The new case of Ebola diagnosed in New York City has raised "even more questions about procedures in treating patients and risks to Americans," a Republican committee chairman said Friday.

Aid group: Ebola contagion risk can't be zero

1 hour ago

Despite stringent infection-control measures, the risk of Ebola's spread cannot be entirely eliminated, Doctors Without Borders said Friday after one of its doctors caught the dreaded disease while working in Guinea and went ...

WHO eyes mass Ebola vaccines by mid-2015

1 hour ago

Hundreds of thousands of Ebola vaccine doses could be rolled out to west Africa by the middle of next year, the World Health Organization said Friday, after new cases of the killer virus were reported in New York and Mali.

User comments : 0