Family study bolsters link between pesticides and Parkinson's

Mar 28, 2008

For the first time, the association between Parkinson’s disease and exposure to pesticides has been shown in patients with the neurological disorder compared with their unaffected relatives, according to a study in the online open access journal BMC Neurology.

Parkinson’s disease is a common neurological disorder affecting about 1 million people in the USA. The disorder typically develops in later life resulting in symptoms such as tremors and muscle rigidity

Although variations in several genes have been identified that contribute to the disease, these rare genetic defects account for a small proportion of the overall prevalence of the disorder.

The majority of Parkinson’s disease cases are thought to be due to an interaction between genetic and environmental factors.

“Previous studies have shown that individuals with Parkinson’s disease are over twice as likely to report being exposed to pesticides as unaffected individuals” says the study’s lead author, Dana Hancock, “but few studies have looked at this association in people from the same family or have assessed associations between specific classes of pesticides and Parkinson’s disease.”

The study of related individuals who share environmental and genetic backgrounds that might contribute to Parkinson’s disease enables researchers to identify specific differences in exposures between individuals with and without the disease. The research team from Duke University Medical Center (Durham, NC) and the University of Miami Miller School of Medicine Morris K. Udall Parkinson Disease Research Center of Excellence (Miami, FL, USA) recruited 319 patients and over 200 relatives. They used telephone interviews to obtain histories of pesticide exposure, living or working on a farm, and well-water drinking.

The authors detected an association between pesticide use and Parkinson’s disease. Among these, the strongest were between the disorder and use of herbicides and insecticides, such as organochlorides and organophosphates. No association was found between Parkinson’s disease and well-water drinking or living or working on a farm, which are two commonly used proxies for pesticide exposures.

Many studies have supported pesticides as a risk factor for PD, but “biological evidence is presently insufficient to conclude that pesticide exposure causes PD”, says Hancock. “Further investigation of these specific pesticides and others may lead to identification of pertinent biological pathways influencing PD development.” In addition future genetic studies of Parkinson’s disease should consider the influence of pesticides, since exposure to pesticides may provide a trigger for the disease in genetically predisposed individuals.

Source: BioMed Central

Explore further: Antibiotic commonly prescribed for bladder infections less effective than others

Related Stories

Two pesticides associated with Parkinson's disease: study

Feb 12, 2011

New research shows a link between use of two pesticides, rotenone and paraquat, and Parkinson's disease. People who used either pesticide developed Parkinson’s disease approximately 2.5 times more often than non-users.

Pesticide levels in blood linked to Parkinson's disease

Jul 13, 2009

July 13, 2009 - People with Parkinson's disease have significantly higher blood levels of a particular pesticide than healthy people or those with Alzheimer's disease, researchers at UT Southwestern Medical ...

Recommended for you

An explanation of wild birds' role in avian flu outbreak

1 hour ago

Wild birds are believed to be behind the first major widespread outbreak of bird flu in the United States, with the virus confirmed in the animals in 10 states. Here are some questions and answers about how wild birds remain ...

Gastroenterology Special Issue confirms: You are what you eat

4 hours ago

Patients are always interested in understanding what they should eat and how it will impact their health. Physicians are just as interested in advancing their understanding of the major health effects of foods and food-related ...

Gonorrhoea and syphilis in Norway in 2014

6 hours ago

Reported cases of gonorrhea continue to increase in Norway, both among men who have sex with men (MSM) and among heterosexuals. The increase of gonorrhea among heterosexual women was particularly significant. ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

SDMike
not rated yet Mar 29, 2008
Duh!

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.