Blueberry and green tea containing supplement protects against stroke damage

Mar 04, 2008

A unique dietary supplement called NutraStem has been shown to have beneficial effects following experimental stroke. A nutritional supplement product, NutraStem also known as NT-020, is a proprietary formulation of blueberry, green tea, vitamin D3 and carnosine extracts- a combination of nutritional ingredients thought to be potent in protecting against brain damage.

“Stroke is the third leading cause of death and the leading cause for disability in the U.S. with two of every 1,000 adults experiencing their firsts stroke in any given year,” said Cesar V. Borlongan, PhD, of the Medical College of Georgia, lead author of a study that tested NT-020 post stroke effects in animal models. “We explored how increasing the nutritive diet through NT-020 supplementation might render a therapeutically potent neurogenesis following stroke.”

NutraStem was developed by Natura Therapeutics, Inc., based in Tampa, Florida and founded by neuroscientists from the University of South Florida.. NutraStem was designed to encourage the proliferation of adult stem cells, which have the potential to develop into most tissues and bone cells in the body and have the capacity to migrate toward problem or damaged areas.

A study, conducted jointly by scientists at the University of South Florida College of Medicine (Tampa) and the Medical College of Georgia (Augusta), examined two groups of laboratory animals in a double-blind procedure. One group received the dietary supplement for two weeks prior to undergoing surgical stroke. The second group did not receive the dietary supplement. Results, published online in the high-impact journal REJUVENATION RESEARCH ), showed that the group receiving NutraStem had greatly reduced neural damage in the brain and demonstrated significantly reduced motor deficits.

”The numbers of new neurons found in the damaged brain of the treated rats was significantly higher,” said co-author Paula Bickford, PhD, of the University of South Florida College of Medicine and co-founder of Natura Therapeutics, Inc. “An important feature of our results is that the combination of agents used was 100 times more potent than previously published study results that examined each of the individual ingredients used by themselves.”

Co-author Cyndy D. Sanberg, PhD, of Natura Therapeutics, Inc., noted that while eliminating detrimental calories has been found to be protective against stroke by reducing oxidative stress, the nutritive diet of NutraStem could enhance and augment that approach.

“Our study found robust neuroprotective effects of the NT-020 formula,” said Borlongan. “Two weeks of NutraStem therapy lessened stroke-induced behavioral deficits, reduced stroke-induced infarcts and promoted the birth of new neurons. Our results provide a critical advance in the scientific and clinical arena by demonstrating the advantage of a multi-agent over a single agent regimen.”

Citation: Yasuhara, T., Hara, Koichi, H., Maki, M., Masuda, T., Sanberg, C.D., Sanberg, P.R., Bickford, P.C., and Borlongan, C.V. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation Research, 11(1), 2008, 201-214.

Source: Cell Transplantation Center of Excellence for Aging and Brain Repair

Explore further: CDC charges Johns Hopkins to lead development of Ebola training module

add to favorites email to friend print save as pdf

Related Stories

Jerusalem stone may answer Jewish revolt questions

9 minutes ago

Israeli archaeologists said Tuesday they have discovered a large stone with Latin engravings that lends credence to the theory that the reason Jews revolted against Roman rule nearly 2,000 ago was because of their harsh treatment.

Turner channels removed from Dish amid pact spat

19 minutes ago

Channels such as Cartoon Network and CNN are no longer part of Dish's programming lineup as a deadline has passed for the satellite TV provider and Turner Broadcasting to renew their distribution agreement.

Google's streaming music service adds mood to mix

19 minutes ago

Google's music-subscription service will try to anticipate its listeners' mood swings as it amplifies its competition with Pandora, Spotify and other popular services that play tunes over the Internet.

Kung fu stegosaur

40 minutes ago

Stegosaurs might be portrayed as lumbering plant eaters, but they were lethal fighters when necessary, according to paleontologists who have uncovered new evidence of a casualty of stegosaurian combat. The ...

Recommended for you

Study reveals state of crisis in Canadian foster care system

23 hours ago

A new study of foster care in Canada led by a researcher at Western University reveals a shrinking number of foster care providers are available across the country to care for a growing number of children with increasingly ...

Researchers prove the benefits of persimmons for diet

Oct 24, 2014

Alba Mir and Ana Domingo, researchers from the Department of Analytical Chemistry of the University of Valencia, under the supervision of professors Miguel de la Guardia and Maria Luisa Cervera, from the same department, ...

Hand blenders used for cooking can emit persistent chemicals

Oct 24, 2014

Eight out of twelve tested models of hand blenders are leaking chlorinated paraffins when used according to the suppliers' instructions. This is revealed in a report from Stockholm University where researchers analyzed a ...

User comments : 0