Adult stem cells may be beneficial for certain cardiovascular disorders and autoimmune diseases

Feb 26, 2008

A review of previously published research suggests that stem cells harvested from an adult’s blood or marrow may provide treatment benefit to select patients for some autoimmune diseases and cardiovascular disorders, according to an article in the February 27 issue of JAMA.

In broad terms, there are two types of stem cells, embryonic stem cells and adult stem cells. Human embryonic stem cells are isolated from a 4- to 5-day-old postfertilization blastocyst (an early form in the development of an embryo). Adult stem cells are located in tissues throughout the body and function as a reservoir to replace damaged or aging cells. Stem cell therapy is rapidly developing and shows great promise, “but clinical application has lagged due to ethical concerns or difficulties in harvesting or safely and efficiently expanding sufficient quantities. In contrast, clinical indications for blood-derived (from peripheral or umbilical cord blood) and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing,” the authors write.

Richard K. Burt, M.D., of the Northwestern University Feinberg School of Medicine, Chicago, and colleagues conducted a review of articles regarding clinical indications and outcomes for use of blood- and bone marrow-derived stem cells. A search of databases identified 323 reports that were examined for feasibility and toxicity, and 69 that were evaluated for outcomes. These studies were published between January 1997 and December 2007.

For autoimmune diseases, 26 reports representing 854 patients reported treatment-related mortality of less than one percent (2/220 patients) for nonmyeloablative (not causing bone marrow suppression), less than two percent (3/197) for dose-reduced myeloablative, and 13 percent (13/100) for intense myeloablative regimens, i.e., those including total body irradiation or high-dose busulfan (a drug used in the treatment of some types of chronic leukemia).

“While all trials performed during the inflammatory stage of autoimmune disease suggested that transplantation of hematopoietic [formation of blood or blood cells] stem cells (HSCs) may have a potent disease-remitting effect, remission duration remains unclear, and no randomized trials have been published,” the researchers write.

For reports involving cardiovascular diseases, including 17 reports involving 1,002 heart attack patients, 16 reports involving 493 patients with chronic coronary artery disease, and three meta-analyses, the evidence suggested that stem cell transplantation performed in patients with coronary artery disease may contribute to modest improvement in cardiac function.

“Stem cells harvested from blood or marrow, whether administered as purified HSCs or mesenchymal [cells that develop into connective tissue, blood vessels and lymphatic tissue] stem cells or as an unmanipulated or unpurified product can, under appropriate conditions in select patients, provide disease-ameliorating effects in some autoimmune diseases and cardiovascular disorders. Clinical trials are needed to determine the most appropriate cell type, dose, method, timing of delivery, and adverse effects of adult HSCs for these and other nonmalignant disorders,” the authors conclude.

Source: JAMA and Archives Journals

Explore further: Stem cells faulty in Duchenne muscular dystrophy

add to favorites email to friend print save as pdf

Related Stories

Habitual use of fire as told from cave near Haifa

25 minutes ago

Scientists have not been content with the exercise of dating when man first used fire. While the earliest evidence for hominin use of fire dates to more than a million years ago, scientists have been keen ...

People finding their 'waze' to once-hidden streets

15 hours ago

When the people whose houses hug the narrow warren of streets paralleling the busiest urban freeway in America began to see bumper-to-bumper traffic crawling by their homes a year or so ago, they were baffled.

Identity theft victims face months of hassle

15 hours ago

As soon as Mark Kim found out his personal information was compromised in a data breach at Target last year, the 36-year-old tech worker signed up for the retailer's free credit monitoring offer so he would ...

Observers slam 'lackluster' Lima climate deal

16 hours ago

A carbon-curbing deal struck in Lima on Sunday was a watered-down compromise where national intransigence threatened the goal of a pact to save Earth's climate system, green groups said.

Your info has been hacked. Now what do you do?

16 hours ago

Criminals stole personal information from tens of millions of Americans in data breaches this past year. Of those affected, one in three may become victims of identity theft, according to research firm Javelin. ...

New Bond script stolen in Sony hack

16 hours ago

An "early version" of the screenplay for the new James Bond film was the latest victim of a massive hacking attack on Sony Pictures Entertainment, its producers said in a statement on their website Sunday.

Recommended for you

Stem cells faulty in Duchenne muscular dystrophy

4 hours ago

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have ...

Here's how the prion protein protects us

9 hours ago

The cellular prion protein (PrPC) has the ability to protect the brain's neurons. Although scientists have known about this protective physiological function for some time, they were lacking detailed knowledge ...

Regulation of maternal miRNAs in early embryos revealed

10 hours ago

The Center for RNA Research at the Institute for Basic Science (IBS) has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.