Chopped up proteins trigger autoimmunity

Jan 24, 2008

Multipotent adult progenitor stem cells extracted from bone marrow, and known as MAPCs, have proved to be effective in the regeneration of blood vessel tissue and also in muscle tissue when treating peripheric vascular disease.

He has also discovered that PM/Scl-75, one of the components from which the exosome is built, is cut as soon as a cell dies. Finally, Schilders has identified an exosome-associated protein that is also frequently recognised by antibodies. These antibodies possibly form an interesting additional marker for the diagnosis of the PM/Scl overlap syndrome.

In people who suffer from an autoimmune disease, the immune system has been disrupted to such an extent that it produces antibodies against a person’s own substances. In polymyositis/sclerodermia (PM/Scl) overlap syndrome these antibodies are targeted at the exosome.

This complex of proteins is involved in the degradation of RNA in the cell. RNA forms an essential link in the flow of information in a cell and, therefore, a strict control over the degradation of RNA is vitally important.

Source: Netherlands Organization for Scientific Research

Explore further: Newly discovered hormone mimics the effects of exercise

add to favorites email to friend print save as pdf

Related Stories

New detection technologies for bacterial pathogens

Feb 19, 2015

In FP7 jargon, RAPTADIAG is categorised as a 'small or medium-scale focused research project'. However, the past two years have seen the consortium turn a novel diagnostic test for bacterial meningitis into ...

Lab-on-a-chip to study single cells

Feb 13, 2015

Scientists at EPFL have developed a new lab-on-a-chip technique to analyze single cells from entire population. The new method, which uses beads and microfluidics can change the way we study mixed populations ...

Locking mechanism found for 'scissors' that cut DNA

Dec 24, 2014

Researchers at Johns Hopkins have discovered what keeps an enzyme from becoming overzealous in its clipping of DNA. Since controlled clipping is required for the production of specialized immune system proteins, ...

The many faces of the bacterial defense system

Apr 30, 2013

Even bacteria have a kind of "immune system" they use to defend themselves against unwanted intruders – in their case, viruses. Scientists at the Helmholtz Center for Infection Research (HZI) in Braunschweig, ...

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.