Trials find no benefits of Zetia

Jan 15, 2008

The U.S. makers of the cholesterol-lowering drug Zetia say a clinical trial failed to identify any medical benefits of the medication.

Merck and Schering-Plough, the New Jersey companies that jointly market Zetia and Vytorin, a drug that combines Zetia with the cholesterol drug Zocor, said that while Zetia has been shown to reduce cholesterol by 15 percent to 20 percent in most patients, it was not found to reduce the risk of heart attacks or strokes, The New York Times reported Monday.

The trial also found no evidence the drug reduces the growth of fatty plaque in arteries. The trial had been designed to show the drug could fight growth of plaque.

Dr. Steven Nissen, chairman of cardiology at the Cleveland Clinic, called the results "shocking" and said patients should not take Zetia unless all other cholesterol drugs have been tried and failed.

"This is as bad a result for the drug as anybody could have feared," he said.

Copyright 2008 by United Press International

Explore further: FDA approves new drug for rare genetic disease

add to favorites email to friend print save as pdf

Related Stories

Merck 2Q profit more than doubles

Jul 29, 2014

A big one-time gain and a tax benefit helped drugmaker Merck & Co. more than double its second-quarter profit, raise the lower end of its profit forecast and easily top analysts' expectations.

Cholesterol: The good, the bad, the unknown

Feb 21, 2011

Two people are diagnosed with high cholesterol, one of the leading risk factors for heart disease, and follow similar therapies. One ends up with improved cholesterol levels, but the other doesn't.

Study raises new questions about Merck pill Zetia

Nov 16, 2009

(AP) -- A new study raises fresh concerns about Zetia and its cousin, Vytorin - drugs still taken by millions of Americans to lower cholesterol, despite questions raised last year about how well they work.

FDA won't accept Merck's application for new drug

Nov 02, 2009

(AP) -- U.S. regulators have refused to accept drugmaker Merck & Co.'s application for a new, combination cholesterol pill that includes rival Pfizer's Lipitor, the world's top-selling drug.

Recommended for you

Boxed warnings are common in novel therapeutics

Aug 19, 2014

(HealthDay)—Boxed warnings are common on recent drug approvals, and many occur years after approval, according to a research letter published online Aug. 15 in JAMA Internal Medicine.

AstraZeneca says DOJ closes probe into drug trial

Aug 19, 2014

British drugmaker AstraZeneca says the U.S. Department of Justice has closed its investigation into a clinical trial of the company's blood thinner Brilinta, and plans no further action.

Perampanel for epilepsy: Still no proof of added benefit

Aug 19, 2014

The drug perampanel (trade name Fycompa) has been approved since July 2012 as adjunctive ("add-on") therapy for adults and children aged 12 years and older with epileptic fits (seizures). In a new early benefit assessment ...

User comments : 0