Cholesterol-lowering drug linked to sleep disruptions

Nov 07, 2007

A cholesterol-lowering drug appears to disrupt sleep patterns of some patients, researchers reported at the American Heart Association’s Scientific Sessions 2007.

“The findings are significant because sleep problems can affect quality of life and may have adverse health consequences, such as promoting weight gain and insulin resistance,” said Beatrice Golomb, M.D., lead author of the study and an associate professor of medicine and family and preventive medicine at the University of California at San Diego School of Medicine.

In the largest study of its kind, researchers compared two types of cholesterol-lowering drugs called statins — simvastatin, which is lipophilic (soluble in fats), and pravastatin, which is hydrophilic (soluble in water).

Because simvastatin is fat soluble it can more readily penetrate cell membranes and cross the blood brain barrier into the brain. The brain controls sleep, and many of the brain’s nerve cells are wrapped in a fatty insulating sheath called myelin.

“The results showed that simvastain use was associated with significantly worse sleep quality. A significantly greater number of individuals taking simvastatin reported sleep problems than those taking either pravastain or the placebo,” Golomb said. “On average, the lipophilic statin had a greater adverse effect on sleep quality.”

In past studies and case reports, some people on statins reported having insomnia or nightmares.

“Several small studies were done early on, including those focused on lipophilic versus hydrophilic statins,” Golomb said. “Most (researchers) didn’t see a difference in sleep, but they had short durations of follow-up and enrolled just a handful of people — often fewer than 20, which was not enough to see a difference unless it was very large.

“One of these studies did report a significant difference between pravastatin and simvastatin. But without more and bigger studies, an effect was not considered to be established.”

In this study, researchers tested 1,016 healthy adult men and women for six months in a randomized, double-blind, placebo-controlled trial using simvastatin, given at 20 milligrams (mg), pravastatin at 40 mg, or a placebo. They assessed outcomes with the Leeds sleep scale, a visual analog scale of sleep quality, and a rating scale of sleep problems. Both scales were measured before and during treatment.

“Those who reported developing much worse sleep on study medication also showed a significant adverse change in aggression scores compared to others,” Golomb said “We should also point out that although the average effect on sleep was detrimental on simvastatin, this does not mean that everyone on simvastatin will experience worse sleep.”

Researchers did not include patients with heart disease or diabetes due to concerns about assigning these people to placebos.

“Patients taking simvastatin who are having sleep problems should consult with their doctor,” Golomb said. “Sleep deprivation is a major problem in a minor number of people.”

Source: American Heart Association

Explore further: Xtoro approved for swimmer's ear

add to favorites email to friend print save as pdf

Related Stories

Microbiome may have shaped early human populations

4 hours ago

We humans have an exceptional age structure compared to other animals: Our children remain dependent on their parents for an unusually long period and our elderly live an extremely long time after they have ...

Big-data analysis reveals gene sharing in mice

4 hours ago

Rice University scientists have detected at least three instances of cross-species mating that likely influenced the evolutionary paths of "old world" mice, two in recent times and one in the distant past.

Recommended for you

Xtoro approved for swimmer's ear

10 hours ago

(HealthDay)—Xtoro (finafloxacin otic suspension) eardrops have been approved by the U.S. Food and Drug Administration to treat swimmer's ear, clinically known as acute otitis externa.

Drug interaction identified for ondansetron, tramadol

10 hours ago

(HealthDay)—In the early postoperative period, ondansetron is associated with increased requirements for tramadol consumption, according to a review and meta-analysis published online Dec. 10 in Anaesthesia.

New system targets germs in donated blood plasma

Dec 17, 2014

(HealthDay)—A new system designed to eliminate germs in donated blood plasma and reduce the risk of transmitting a plasma-borne infection has been approved by the U.S. Food and Drug Administration.

Judge halts Alzheimer's drug swap until July

Dec 16, 2014

A federal judge has ordered an Irish drug manufacturer to halt its plans to discontinue its widely used Alzheimer's medication, allegedly in an effort to drive patients to a newer patented drug.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.