Enzyme promotes fat formation

Oct 12, 2007

The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week. The enzyme, TPPII, has previously been linked to making people feel hungry, but Jonathan Graff and colleagues now show that it may be even more deeply involved in causing obesity.

The team found that TPPII actually stimulated the formation of fat cells in worms and mammalian cells and that by reducing it, fat stores decreased. Mice with lower levels of TPPII were thinner than their wild type littermates, although their food intake was comparable.

The authors hope that TPPII could be exploited as a drug target to help fight increasing levels of obesity; inhibiting the enzyme would both increase feelings of fullness after eating and decrease build up of fat cells.

Around 40 million Americans are obese and the UK Government predicts that 12 million adults in the UK will be obese by 2010 if nothing is done. Obesity is responsible for 70% of cardiovascular diseases and 80% of type II diabetes and represents a serious health risk and financial drain.

Source: European Molecular Biology Organization

Explore further: Research team treats brain injuries in mice using bone marrow stem cells and antioxidants

add to favorites email to friend print save as pdf

Related Stories

ICANN chief urges wide Internet control

10 hours ago

The head of the private agency that acts as gatekeeper for the Internet called Tuesday for international discussions to ensure control of the web remains decentralised.

Image descriptions from computers show gains

10 hours ago

"Man in black shirt is playing guitar." "Man in blue wetsuit is surfing on wave." "Black and white dog jumps over bar." The picture captions were not written by humans but through software capable of accurately ...

Twitter indexes every public tweet ever sent

11 hours ago

Twitter on Tuesday began letting users search through every tweet publicly fired off at the globally-popular one-to-many messaging service since it launched in 2006.

Recommended for you

Organovo has 3D-printed liver tissue for drug testing

Nov 20, 2014

(Medical Xpress)—The commercial release of 3D printed liver tissue was announced earlier this week. Organovo is the company behind the release. The product is intended for use for preclinical drug discovery ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.