Enzyme promotes fat formation

Oct 12, 2007

The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week. The enzyme, TPPII, has previously been linked to making people feel hungry, but Jonathan Graff and colleagues now show that it may be even more deeply involved in causing obesity.

The team found that TPPII actually stimulated the formation of fat cells in worms and mammalian cells and that by reducing it, fat stores decreased. Mice with lower levels of TPPII were thinner than their wild type littermates, although their food intake was comparable.

The authors hope that TPPII could be exploited as a drug target to help fight increasing levels of obesity; inhibiting the enzyme would both increase feelings of fullness after eating and decrease build up of fat cells.

Around 40 million Americans are obese and the UK Government predicts that 12 million adults in the UK will be obese by 2010 if nothing is done. Obesity is responsible for 70% of cardiovascular diseases and 80% of type II diabetes and represents a serious health risk and financial drain.

Source: European Molecular Biology Organization

Explore further: Crystal structure reveals how minor variations make receptor proteins activate or inhibit natural killer cells

add to favorites email to friend print save as pdf

Related Stories

Climate impacts of changing aerosol emissions since 1996

1 hour ago

The re-distribution of anthropogenic aerosol emissions from Europe and North America towards China and India between 1996 and 2010 has surprisingly warmed rather than cooled the global climate. This result reinforces the ...

Recommended for you

User comments : 0