Analysis of breast and colon cancer genes finds many areas of differences between tumors

Oct 11, 2007

Researchers from University Hospitals (UH) Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors.

The study, published online by the journal Science on Oct. 11, shows a great number of genetic differences between breast and colon cancer tumors, leading the researchers to conclude that new drugs must be developed that can hit these newly identified genetic targets in a manner specific to each different individual's tumor.

Sanford Markowitz, M.D., Ph.D., the Ingalls Professor of Cancer Research at the UH Ireland Cancer Center and Case Western Reserve University, said, “The new insights gained are important in that they indicate there is great genetic diversity from one tumor to the next. Only a handful of genes are common targets for damage, and it will accordingly be necessary to develop a panel of drugs that target specific mutant genes in order to be able to provide individualized cancer treatment to different individual patients.”

These results also have potential for tumor diagnosis, according to the researchers.

Source: University Hospitals of Cleveland

Explore further: Researchers reveal how pancreatic cancer cells sidestep chemotherapy

add to favorites email to friend print save as pdf

Related Stories

Using viruses to find the cellular Achilles heel

Jan 22, 2015

Back-to-back studies from researchers at the Gladstone Institutes have exposed new battle tactics employed by two deadly viruses: hepatitis C (HCV) and the Kaposi's sarcoma-associated herpesvirus (KSHV). Published in the ...

Living longer, not healthier

Jan 20, 2015

A study of long-lived mutant C. elegans by scientists at the University of Massachusetts Medical School shows that the genetically altered worms spend a greater portion of their life in a frail state and ex ...

Recommended for you

Colon cancer rates rising among Americans under 50

Jan 30, 2015

(HealthDay)—Although the overall rate of colon cancer has fallen in recent decades, new research suggests that over the last 20 years the disease has been increasing among young and early middle-aged American ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.