Analysis of breast and colon cancer genes finds many areas of differences between tumors

Oct 11, 2007

Researchers from University Hospitals (UH) Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors.

The study, published online by the journal Science on Oct. 11, shows a great number of genetic differences between breast and colon cancer tumors, leading the researchers to conclude that new drugs must be developed that can hit these newly identified genetic targets in a manner specific to each different individual's tumor.

Sanford Markowitz, M.D., Ph.D., the Ingalls Professor of Cancer Research at the UH Ireland Cancer Center and Case Western Reserve University, said, “The new insights gained are important in that they indicate there is great genetic diversity from one tumor to the next. Only a handful of genes are common targets for damage, and it will accordingly be necessary to develop a panel of drugs that target specific mutant genes in order to be able to provide individualized cancer treatment to different individual patients.”

These results also have potential for tumor diagnosis, according to the researchers.

Source: University Hospitals of Cleveland

Explore further: Gene marker may predict breast cancer response to tamoxifen

add to favorites email to friend print save as pdf

Related Stories

Scientists crack the code of a cancer-causing parasite

Jul 15, 2014

Scientists have sequenced the genome and characterised the genes of the Asian liver fluke, Opisthorchis viverrini. This parasite causes diseases that affect millions of people in Asia and is associated with ...

Recommended for you

Pain and itch may be signs of skin cancer

8 hours ago

Asking patients if a suspicious skin lesion is painful or itchy may help doctors decide whether the spot is likely to be cancerous, according to a new study headed by Gil Yosipovitch, MD, Chairman of the Department of Dermatology ...

Genetics of cancer: Non-coding DNA can finally be decoded

12 hours ago

Cancer is a disease of the genome resulting from a combination of genetic modifications (or mutations). We inherit from our parents strong or weak predispositions to developing certain kinds of cancer; in addition, we also ...

User comments : 0