Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding

Sep 19, 2007

An algorithm utilizing structure mapping and thermodynamics is introduced for RNA pseudoknot prediction. The method finds the minimum free energy in the context of the biological folding direction (5’ to 3’) of RNA sequences.

It also identifies information about the flexibility of the RNA. Mapping methods are used to build and analyze the folded structure and add important 3D structural considerations.

The model suggests that many biological RNA molecules are optimized by natural selection to fold correctly in the natural context and that stable intermediate RNA secondary structure can persist that anticipates pseudoknot formation.

The model will be published in the online, open-access journal PLoS ONE on September 19.

Source: Public Library of Science

Explore further: Compact wool measurement tool may find home on the range

add to favorites email to friend print save as pdf

Related Stories

Building a worldwide genetic library BRIC-by-BRIC

Dec 12, 2014

A house is only as good as its foundation. Built solid and strong, the resulting structure should last for decades. NASA is laying a strong foundation of life science research with results from a recent investigation ...

Making sure antibiotics work as they should

Oct 08, 2014

Researchers at ETH Zurich are decoding the structure of the large ribosomal subunit of the mitochondria at an atomic level, thereby providing insight into the molecular architecture of this ribosome with ...

Recommended for you

Population genomics unveil seahorse domain

13 hours ago

In a finding vital to effective species management, a team including City College of New York biologists has determined that the lined seahorse (Hippocampus erectus) is more a permanent resident of the we ...

Researchers develop new potato cultivar

16 hours ago

Dakota Ruby is the name of a new potato cultivar developed by the NDSU potato breeding project and released by the North Dakota Agricultural Experiment Station. Dakota Ruby has bright red skin, stores well and is intended ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.