Pancreatic cancer fights off immune attack

Aug 30, 2007

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum) and the Heidelberg University Hospitals have discovered that pancreatic cancer attracts regulatory T cells, which suppress the activity of immune cells. In this way, the tumor might escape its destruction by the immune system.

The ability to discriminate between friend and foe or between “self“ and “foreign” is vital for a functioning immune system. There are numerous protective mechanisms at work to save the body’s own tissue from attacks by misguided immune cells. A pivotal role is played by regulatory T cells (Treg cells), which prevent immune reactions against the body’s own structures by suppressing the aggressiveness of particular immune cells called T helper cells.

Malignant tumors actively attract Treg cells and, thus, slow down immune defense to protect themselves against elimination. This is suggested by results just published by Associate Professor Dr. Philipp Beckhove jointly with colleagues from the German Cancer Research Center in collaboration with Professor Jürgen Weitz, Dr. Hubertus Schmitz-Winnenthal and other colleagues from the Heidelberg University Hospitals.

In tissue samples of pancreatic cancer the researchers found a much higher number of Treg cells than in samples obtained from regions of the organ that were not affected by cancer. For other immune cells, such as T helper cells, they found no such differences.

Cells of the immune system, including regulatory T cells, are called to their site of action by specific “address molecules“ on the surface of blood vessel cells (endothelial cells). The presence of address molecules is the signal for immune cells patrolling in the bloodstream to squeeze through the vessel wall in order to enter the adjacent tissue. Beckhove and colleagues have shown that Treg cells easily pass through a layer of endothelial cells isolated from tumor tissue.

If, however, the endothelial cells originate from healthy tissue, then a significantly lower number of Treg cells make their way through the layer of cells. The researchers also discovered why this is so: Endothelial cells from tumor tissue carry significantly more address molecules on their surface than vessel cells from healthy regions of the pancreas. When the investigators made these adresses invisible using specific antibodies, the Treg accumulation in the tumor tissue was stopped.

“Treatment possibilities for pancreatic carcinoma, in particular, are still insufficient. Specific antibodies preventing the accumulation of Treg cells in the tumor and, thus, strengthening immune defense, might be a useful therapeutic option,” says Phillip Beckhove to explain the relevance of these results.

Source: Deutsches Krebsforschungszentrum

Explore further: Suppressing a protein reduces cancer spread in mice

add to favorites email to friend print save as pdf

Related Stories

How does space travel affect organ development?

Dec 10, 2014

The crew of the International Space Station will soon be joined by 180 mice from Berkeley Lab. Their mission: help scientists learn how space travel affects the immune system, organ development, and reproduction ...

Recommended for you

Suppressing a protein reduces cancer spread in mice

2 hours ago

Scientists have found that decreasing the levels of or blocking a specific protein commonly found in humans and many other animals allowed them to slow the spread of two different kinds of cancer to the lungs ...

Bone loss drugs may help prevent endometrial cancer

12 hours ago

A new analysis suggests that women who use bisphosphonates—medications commonly used to treat osteoporosis and other bone conditions—have about half the risk of developing endometrial cancer as women who do not use the ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.