Surgery for severe obesity saves lives

Aug 23, 2007

An extensive swedish study from the Sahlgrenska Academy has established that surgery reduces premature death in patients with severe obesity. A long-term follow up has shown that mortality is significantly lower among patients who undergo surgery than among those who do not. The results are published today in The New England Journal of Medicine.

“We show for the first time that surgery against obesity not only leads to long-term loss of weight, it also significantly reduces mortality", says Lars Sjöström, professor emeritus at the Sahlgrenska Academy, located in Göteborg in Sweden.

Over 4,000 severely obese patients were included in the study, which Lars Sjöström started as long ago as 1987. Half of these patients underwent stomach surgery (bariatric surgery) intended to give weight loss. The remaining patients received advice concerning changes in lifestyle, also intended to give weight loss. Some of these patients also received medicines for weight loss, but even so, the conventional treatment was considerably less effective than the surgical procedure.

“The group receiving conventional treatment had even increased somewhat in weight after 10 years, while patients who had undergone surgery decreased in weight by 16%, on average. Bariatric surgery is the only treatment for severe obesity for which there is scientific evidence that it reduces mortality", says Lena Carlsson, professor at the Sahlgrenska Academy.

A long-term follow up for between 5 and 18 years of the patients who had undergone surgery showed that mortality among these patients was 29% lower than it was among the other patients.

“The mechanisms behind the lower mortality are not clear. It seems that the reduction in risk depends less upon the actual loss of weight itself than on the fact that the patients have undergone surgery against obesity. This observation opens new possibilities for discovering previously unknown mechanisms behind the increase in risk associated with obesity, and thus opens the possibility of developing new treatments", says Lars Sjöström.

The researchers also considered the effects of many biochemical and other variables in the analysis, including smoking, stress and previous medical history.

Source: Swedish Research Council

Explore further: AbbVie to buy leukemia drugmaker Pharmacyclics for $21B

add to favorites email to friend print save as pdf

Related Stories

Cancer prevalent in pets but treatable, says veterinarian

Dec 03, 2014

About 50 percent of dogs and 33 percent of cats age 10 years and older will develop cancer. Although it is very prevalent in these animals, a Kansas State University veterinarian says depending upon the type of cancer, it ...

A smart prosthetic knee with in-vivo diagnoses

Apr 22, 2014

The task was to develop intelligent prosthetic joints that, via sensors, are capable of detecting early failure long before a patient suffers. EPFL researchers have taken up the challenge.

Recommended for you

Uganda on defensive over medical 'brain drain' uproar

Mar 03, 2015

Uganda's government on Tuesday hit back at mounting criticism of plans to 'export' over 200 health workers to the Caribbean, insisting it was only seeking to regulate an existing labour market and prevent abuses.

Seth Mnookin on vaccination and public health

Mar 02, 2015

Seth Mnookin, an assistant professor of science writing and associate director of MIT's Graduate Program in Science Writing, is the author of "The Panic Virus: The True Story Behind the Vaccine-Autism Controversy" ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.