Aspirin resistant proteins are identified

Jun 26, 2007

Spanish scientists have identified blood proteins that might create aspirin resistance that keeps thousands of people from reaping aspirin's benefits.

Antonio Lopez-Farre, Carlos Macaya and colleagues at Clinico Hospital San Carlos in Madrid used a powerful technology called two-dimensional electrophoresis to study changes in different proteins present in two groups of patients with coronary artery disease, the underlying cause of most heart attacks.

One group of patients was aspirin-sensitive and the other had aspirin resistance.

The researchers found increased levels of three proteins involved in the binding of vitamin D in patients with aspirin resistance. They also demonstrated those proteins can inhibit aspirin's effects in preventing blood clots.

The researchers said their findings might aid in the development of more effective therapies for aspirin-resistant patients.

The study is scheduled for publication in the July 6 issue of the Journal of Proteome Research.

Copyright 2007 by United Press International

Explore further: B and T cell-targeting drug ameliorates chronic graft-versus-host disease in mice

add to favorites email to friend print save as pdf

Related Stories

Some anti-inflammatory drugs affect more than their targets

Aug 21, 2014

Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved ...

Curry spice could offer treatment hope for tendinitis

Aug 09, 2011

(PhysOrg.com) -- A derivative of a common culinary spice found in Indian curries could offer a new treatment hope for sufferers of the painful condition tendinitis, an international team of researchers has shown.

Recommended for you

Scientists aim to give botox a safer facelift

17 hours ago

New insights into botulinum neurotoxins and their interactions with cells are moving scientists ever closer to safer forms of Botox and a better understanding of the dangerous disease known as botulism. By comparing all known ...

User comments : 0