Resistant gut bacteria will not go away by themselves

Jun 19, 2007

E. coli bacteria that have developed resistance to antibiotics will probably still be around even if we stop using antibiotics, as these strains have the same good chance as other bacteria of continuing to colonise the gut, according to a thesis at the Sahlgrenska Academy.

E. coli bacteria are found naturally in large quantities in our intestines. These bacteria do not normally cause disease, but there are several strains that can result in diarrhoea. In serious cases, they can also cause peritonitis and septicaemia.

The faeces of 128 Swedish infants were analysed in the studies underlying the thesis. The results show that 21% of E. coli strains in these infants’ gut flora were resistant to at least one type of antibiotic. Even children who had never been given antibiotics had resistant bacterial strains in their intestines.

“This is a growing problem, and it’s serious even when ordinary harmless bacteria develop resistance, as these genes can be transferred to more harmful bacteria,” says microbiologist Nahid Karami.

Many had thought that resistant bacteria would disappear if the use of antibiotics were to be reduced, but the thesis shows that E. coli strains carrying resistance genes are just as good at colonising the gut for long periods as sensitive strains.

”Our research suggests that there’s little cost to the bacteria from carrying a resistance gene, and this presumably means that this resistance will be retained for a long time by the bacteria in our gut flora even if we stop using antibiotics,” says Karami.

Bacteria have a natural ability to absorb and transfer resistance genes to other bacteria. The study discovered two cases of such transfers between E. coli strains found simultaneously in a child’s intestines. The first was in an infant who was treated with penicillin, and the second in an infant who was not treated with antibiotics.

“Our results suggest that the transfer of resistance genes in the gut flora may be very common, which makes the resistance issue much more serious, as genes can easily be transferred from bacteria in the normal flora to more harmful bacteria,” says Karami.

Source: Swedish Research Council

Explore further: Ultrasound enhancement provides clarity to damaged tendons, ligaments

add to favorites email to friend print save as pdf

Related Stories

Battling superbugs with gene-editing system

16 hours ago

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, infect ...

'Immortal' flatworms may be a weapon against bacteria

Sep 11, 2014

A novel mode of defense against bacteria such as the causal agent of tuberculosis or Staphylococcus aureus has been identified in humans by studying a small, aquatic flatworm, the planarian. This discovery ...

Bacteria harbor secret weapons against antibiotics

Sep 09, 2014

The ability of pathogenic bacteria to evolve resistance to antibiotic drugs poses a growing threat to human health worldwide. And scientists have now discovered that some of our microscopic enemies may be ...

Recommended for you

A better way to track emerging cell therapies using MRIs

Sep 19, 2014

Cellular therapeutics – using intact cells to treat and cure disease – is a hugely promising new approach in medicine but it is hindered by the inability of doctors and scientists to effectively track the movements, destination ...

User comments : 0