To burn sugar or not to burn sugar: How eggs store fuel for embryo development

January 28, 2016
Artist's depiction of mitochondria, courtesy of Matthew Sieber. The purple on the outside border represents the outer mitochondrial membrane. The blue on the inside depicts the mitochondrial inner membrane space. The green and purple inside depicts the inner mitochondrial membrane and mitochondrial matrix. Credit: Matthew Sieber

Reproduction is highly dependent on diet and the ability to use nutrients to grow and generate energy. This is clearly seen in women, who must provide all the nutritional building blocks required to support a growing embryo. As a result, metabolic diseases like diabetes and obesity are closely linked with several female reproductive disorders such as: Infertility, polycystic ovary syndrome, and ovarian cancer. However, the precise links between reproductive processes and metabolism remains poorly understood.

In a recent study, published in Cell, Carnegie's Matthew Sieber, Michael Thomsen, and Allan Spradling use the fruit fly as a system to dissect the links between metabolism and the development of eggs. As eggs, also known as oocytes, enter the final stages of development, they accumulate large amounts of proteins, lipids and sugars in order to fuel the embryo after fertilization. The Spradling lab was able to identify a functional and biochemical change in the developing oocytes that induces carbohydrate storage.

Mitochondria are the structures within cells that convert nutrients, such as sugar, into energy that fuels the cell, allowing it to function and grow. Sieber, Thomsen, and Spradling found that during the final stages of oocyte development, insulin signaling is inactivated in oocytes, causing a fundamental change in the biochemical properties of the mitochondria and a reduction in mitochondrial activity. This change in mitochondrial function leads to a build-up of sugars in the oocyte. As a result, these sugars can then be used after fertilization to fuel the developing embryo.

Insect ovaries are composed of tubes, called ovarioles, one of which is shown here. It is stained with a mitochondrial membrane-potential stain. The more red/white the color is, the higher the mitochondrial membrane potential, and in turn the higher mitochondrial activity it represents. You could think of this as a heat scale with the white/red colors being the most active and the blue/black colors having the lowest activity. Credit: Matthew Sieber

Their findings are consistent with previous observations that show mammalian oocytes also display low levels of , suggesting similar changes in and sugar storage may be an essential aspect of oocyte production in many species.

"We believe our findings are directly applicable to understanding human infertility," Spradling said. "Polycystic ovary syndrome is the leading cause of female infertility and it is strongly associated with diabetes and insulin resistance, which suggests that defects in the metabolic aspects of oocyte maturation may be the underlying source of the disorder."

Furthermore, the Spradling team believes that mitochondrial defects during oocyte development may contribute to that fail during in vitro fertilization treatment (IVF), although further research is required.

Explore further: Steroid links fat accumulation with egg development

Related Stories

Steroid links fat accumulation with egg development

March 19, 2015

Nutrition and metabolism are closely linked with reproductive health. Several reproductive disorders including polycystic ovary syndrome, amenorrhea, and ovarian cancer have been linked to malnutrition, diabetes, and obesity. ...

Mutations in TUBB8 linked to form of female infertility

January 21, 2016

(HealthDay)—For a small number of women with a rare form of infertility, mutations in a particular gene may be the cause, according to a study published in the Jan. 21 issue of the New England Journal of Medicine.

Singapore scientists discover rejuvenation factors

August 13, 2015

Scientists from A*STAR's Genome Institute of Singapore (GIS) have discovered metabolic rejuvenation factors in eggs. This critical finding furthers our understanding of how cellular metabolism changes during aging, and during ...

Metabolic means to preserving egg supply and fertility

October 3, 2013

The stresses that come with aging, chemotherapy treatments, and environmental exposures all threaten fertility. But what if there were a way to preserve women's limited egg supply? Researchers reporting on studies conducted ...

Recommended for you

Yeast knockouts peel back secrets of cell protein function

September 26, 2016

Proteins are the hammers and tongs of life, with fundamental roles in most of what happens in biology. But biologists still don't know what thousands of proteins do, and how their presence or absence affects the cell.

How the anthrax toxin forms a deadly 'conveyer belt'

September 26, 2016

Researchers have built a three-dimensional map of the anthrax toxin that may explain how it efficiently transfers its lethal components into the cytoplasm of infected cells. The study, "Structure of anthrax lethal toxin prepore ...

Discovery may benefit farmers worldwide

September 26, 2016

University of Guelph plant scientists have shown for the first time how an ancient crop teams up with a beneficial microbe to protect against a devastating fungal infection, a discovery that may benefit millions of subsistence ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.