Engineered E. coli produces high levels of D-ribose

April 24, 2014
©2014, Mary Ann Liebert, Inc., publishers

D-ribose is a commercially important sugar used as a sweetener, a nutritional supplement, and as a starting compound for synthesizing riboflavin and several antiviral drugs. Genetic engineering of Escherichia coli to increase the bacteria's ability to produce D-ribose is a critical step toward achieving more efficient industrial-scale production of this valuable chemical, as described in an article in Industrial Biotechnology.

In "Engineering Escherichia coli for D-Ribose Production from Glucose-Xylose Mixtures." Pratish Gawand and Radhakrishnan Mahadevan, University of Toronto, Canada, describe the metabolic engineering strategy they used to increase the yield of D-ribose from the genetically modified E. coli, which were able to produce D-ribose from mixtures of glucose and xylose. The authors propose future research directions for additional metabolic engineering and bioprocess optimization.

"The research article by Gawand and Mahadevan represents one of many ways that molecular biology is being deployed to expand Industrial Biotechnology development," says Co-Editor-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY.

Explore further: Production of 5-aminovaleric and glutaric acid by metabolically engineered microorganism

More information: The article is available on the Industrial Biotechnology website.

Related Stories

Metabolically engineered E. coli producing phenol

October 8, 2013

Many chemicals we use in everyday life are derived from fossil resources. Due to the increasing concerns on the use of fossil resources, there has been much interest in producing chemicals from renewable resources through ...

Integrated approaches to customize fungal cell factories

December 19, 2013

The natural ability of certain fungi to break down complex substances makes them very valuable microorganisms to use as cell factories in industrial processes. Advances in metabolic engineering and systems biology are helping ...

Recommended for you

Plant light sensors came from ancient algae

July 28, 2015

The light-sensing molecules that tell plants whether to germinate, when to flower and which direction to grow were inherited millions of years ago from ancient algae, finds a new study from Duke University.

Head and body lice read DNA differently

July 28, 2015

What makes head lice different from body lice had scientists scratching their heads as previous genetic studies failed to find any substantial differences between the two types of lice.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.