Scientists find distinctive patterns of olfactory receptors in fruit-eating bats

Mar 04, 2014 by Cheryl Dybas
The tent-making bat Uroderma bilobatum, a fruit-eating species of New World leaf-nosed bats. Credit: Sebastien Puechmaille, Ernst-Moritz-Arndt University

How do we smell? The answer lies in the 1,000 or so genes that encode what's known as olfactory receptors inside our noses.

This gene superfamily constitutes 3 to 6 percent of a mammal's genes.

But scientists don't completely understand what odors bind to which receptors, and how this complex process translates into interpreting a particular smell.

In fact, little is known about how olfactory receptors function in mammals, or how this large gene family has evolved in response to different evolutionary challenges.

Specialized gene pattern in fruit-eating bats

Now scientists have identified a distinctive olfactory receptor gene pattern in fruit-eating , as well as the particular olfactory receptor gene families important to their fruit diets.

The findings offer new insights that link olfactory receptors with the odors they bind.

The research highlights the importance, the biologists say, of exploring diversity in nature to understand genome functions and evolutionary history in mammals.

Evolutionary biologists Liliana Davalos of Stony Brook University, Emma Teeling of University College Dublin and colleagues report their results in a paper published in this month's' issue of the journal Molecular Biology and Evolution.

A nectar bat, Glossophaga soricina, feeding on the flowers of a banana plant. Credit: Beth Clare, Queen Mary University

"This study provides new insights into the mechanisms that have allowed bats to diversify their diets so extensively," says Simon Malcomber, a program director in the National Science Foundation's Division of Environmental Biology, which funded the research.

This research was also supported by the Science Foundation Ireland and the Irish Research Council.

"We knew that animals that live in various ecological environments—whales, bats, cows—have evolved different suites of olfactory receptors," says Davalos. "That suggests that the ability to smell different odors is important for survival."

Since these lifestyles evolved so long ago, she says, it's difficult to tell what forces have shaped the repertoire of olfactory receptors.

Bats hold key to evolution of smell receptors

Has the evolution of other sensory systems, changes in diet, or the random accumulation of changes through time driven the evolution of olfaction in mammals?

"Bats offer a prime opportunity to answer this question," says Davalos.

"They've evolved new sensory systems such as echolocation, and various bat species eat very different foods, including insects, nectar, fruit, frogs, lizards and even blood."

Skull of the bat Carollia perspicillata (left) and a model of the same bat (right). Credit: Elizabeth Dumont, University of Massachusetts at Amherst

Two large groups of bats branched out since diverging about 64 million years ago. These groups separately evolved specialized echolocation and a diet based on fruit.

The patterns have arisen twice, once among New World leaf-nosed bats that feed primarily on figs and another among Old World fruit bats. The bats feed on variety of fruits, including figs, guavas, bananas, mangoes and other tropical fruits.

Could their evolutionary patterns help explain their olfactory receptors?

Finding fruit by dark of night

After sequencing thousands of olfactory receptors from dozens of bat species and analyzing an evolutionary tree including all the species, the researchers found distinctive patterns of olfactory receptors among bats that specialize in eating fruit.

Although the are similar, the distinctive repertoires have arisen in different ways in New World and Old World bats.

That suggests, Davalos says, that independent mechanisms have shaped this part of the bat genome in response to the challenge of finding fruit by dark of night.

Explore further: Using engineering plus evolutionary analyses to answer natural selection questions

More information: Sara Hayden, Michaël Bekaert, Alisha Goodbla, William J. Murphy, Liliana M. Dávalos, and Emma C. Teeling. "A Cluster of Olfactory Receptor Genes Linked to Frugivory in Bats." Mol Biol Evol first published online January 16, 2014 DOI: 10.1093/molbev/msu043

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JVK
1 / 5 (1) Mar 04, 2014
Excerpt: "Could their evolutionary patterns help explain their olfactory receptors?"

No. Ecological variations predict the ecological adaptations that are enabled by the experience-dependent de novo creation of olfactory receptor genes. The idea that olfactory receptors evolve is ridiculous.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model

http://www.socioa...53/27989

"This model details how chemical ecology drives adaptive evolution via: (1) ecological niche construction, (2) social niche construction, (3) neurogenic niche construction, and (4) socio-cognitive niche construction. This model exemplifies the epigenetic effects of olfactory/pheromonal conditioning, which alters genetically predisposed, nutrient-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction via their effects on luteinizing hormone (LH) and systems biology."

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