An environmentally friendly chemical reaction that does not waste any atoms

March 4, 2014
Postdoc Langui Xie und Nuno Maulide, since October 2013 Full Professor for Organic Synthesis at the University of Vienna, present the new transformation that doesn't waste any atoms. "H+" is the catalyst. Credit: Maulide Group, University of Vienna

In the research group of Nuno Maulide, a chemist working at the University of Vienna, a new chemical synthesis for α-arylated Carbonyl derivatives was developed. Members of this class of substances typically possess interesting biological and pharmacological properties and often find applications as medicines. The new technique developed by the Maulide group, which allows such Carbonyl derivatives to be generated easily, efficiently and in an environmentally friendly manner – without wasting any atoms –, has raised significant scientific interest and awareness.

The corresponding publication in the journal Angewandte Chemie – International Edition was considered by the Editorial office as "highly important".

From accidental discovery to rational design

In Organic Chemistry one often encounters surprising experimental results, e.g. when new properties of compounds or new are unexpectedly discovered. The discovery of a new type of reactivity, i.e. the ability of a to undergo a new type of reaction, can shine light on unforeseen and previously unknown interesting properties of that substance. Ideally, the chemist can then make use of the unexpected result and information to develop new transformations. The phenomenon whereby a scientist can make use of an unexpected result is often termed "Serendipity".

"Our initial, accidental discovery was an unusual transformation of amides – chemical substances that derive formally from the union of ammonia and carboxylic acids. In our current work, the addition of an activating agent generates a reactive intermediate, which subsequently undergoes an elegant rearrangement. During this rearrangement, the atomic constitution of the molecule is altered with atoms effectively changing place in a harmonious manner, leading to an entirely different product. We took advantage of the knowledge gained during that reaction for the development of the current Acid-catalysed Redox-Arylation. In other words, the information obtained during the study of that unexpected transformation allowed us to design novel useful transformations", says Nuno Maulide, since October 2013 Full Professor for Organic Synthesis at the University of Vienna. Maulide had published that original discovery in 2010 in the journal "Angewandte Chemie".

New: Only a catalyst is needed, and no additional reagents

In most organic chemical reactions a modification of the oxidation stage of the reagents takes place. Oxidations increase the oxidation state, whereas reductions decrease that oxidation state. Both types of reactions require the addition of an external reagent, either an oxidant or a reductant. In the new family of so-called "Redox-neutral", both steps – oxidation and reduction – take place simultaneously and concomitantly with the desired transformation. This renders additional reagents unnecessary. "The arylation that we have just developed requires only a catalyst; no other reagents are required", explains Langui Xie, co-author of the current publication and Post-Doc in the very international group of Nuno Maulide at the University of Vienna.

Sustainability: No atoms are wasted

New methods of synthesis for arylated Carbonyl derivatives are of considerable interest for the scientific community – not least due to the very important biological activities of α-arylated carbonyls and their possible applications as medicines. Up to now, most methods employed for their preparation employed Transition-metal catalysed reactions, with the use of heavy metal reagents. This involves inevitable disadvantages such as product contamination, high catalyst costs and laborious and work-intensive reaction conditions. "The new transformation we developed requires no metals and belongs to the group of 'Atom-economical reactions'. Such transformations are notable in that all of the atoms of the reagents are expressed in the final products; thus, no atoms are wasted during the process", concludes the chemist Nuno Maulide.

Explore further: Introduction of fluorine atoms into organic molecules could have applications for synthesis of pharmaceuticals

More information: Bo Peng, Xueliang Huang, Lan-Gui Xie und Nuno Maulide: A Bronsted Acid-Catalyzed Redox Arylation. Angewandte Chemie, Int. Ed. 2014, DOI: 10.1002/anie.201310865

Related Stories

Organic chemistry: Carbon dioxide tamed

January 15, 2014

Carbon dioxide has become notorious as a troublesome greenhouse gas produced by burning fossil fuels. Now, this gas could also offer a cheap, abundant and nontoxic source of carbon for the chemical reactions that synthesize ...

Recommended for you

Findings illuminate animal evolution in protein function

July 27, 2015

Virginia Commonwealth University and University of Richmond researchers recently teamed up to explore the inner workings of cells and shed light on the 400–600 million years of evolution between humans and early animals ...

New polymer able to store energy at higher temperatures

July 30, 2015

(Phys.org)—A team of researchers at the Pennsylvania State University has created a new polymer that is able to store energy at higher temperatures than conventional polymers without breaking down. In their paper published ...

How to look for a few good catalysts

July 30, 2015

Two key physical phenomena take place at the surfaces of materials: catalysis and wetting. A catalyst enhances the rate of chemical reactions; wetting refers to how liquids spread across a surface.

Yarn from slaughterhouse waste

July 29, 2015

ETH researchers have developed a yarn from ordinary gelatine that has good qualities similar to those of merino wool fibers. Now they are working on making the yarn even more water resistant.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.