The complex physical mechanisms in real biomolecule motors

Mar 21, 2014
The complex physical mechanisms in real biomolecule motors
A computer simulation of the motor-rail system. The walking mechanism is explained by the alternation between the bubble and the liquid state.

Computer simulations of relatively simple models provide clues to the complex physical mechanisms at work in real biomolecule motors.

The asymmetric Brownian ratchet model describes a motor particle moving on a rail (for example a protein like kinesin walking a on a microtubule). There are two possible states: in one the particle moves in a random walk along the rail; in the other it feels the asymmetric potential from the rail. Alternating between these two states leads to a directed movement.

A collaboration including the University of Electro-Communications, Keio University, RIKEN, University of Fukui and University of Nebraska-Lincoln led by Noriyoshi Arai previously suggested that the transition between the two states is caused by . Arai and co-workers have now refined their model including a more realistic temperature-controlled switching mechanism.

In their model the two states of the asymmetric Brownian ratchet are a hydrophobic 'bubble state' and a hydrophilic 'liquid state'. In the former, the motor is close to the rail, bubbles form due to the and the motor feels an asymmetric potential. In the latter, the motor is far from the rail and due to thermal fluctuations it moves randomly along it. The switching between the two is caused by the change of hydrophobic/hydrophilic parameter of the motor controlled by the temperature of the motor itself.

As indicate, the mechanism proposed by Arai and collaborators could lead to very efficient walking depending on the material used for the motor, for example thermosensitive polymers.

Explore further: Experiments show hypothesis of microtubule steering accurate

More information: Noriyoshi Arai, et al. "Understanding Molecular Motor Walking along a Microtubule: A Themosensitive Asymmetric Brownian Motor Driven by Bubble Formation." J. Am. Chem. Soc. 135, 8616−8624, (2013).

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