Illumina announces $1000 whole human genome sequencing machine

Jan 16, 2014 by Bob Yirka report

(Phys.org) —Genome sequencing-technology company, Illumina, based in San Diego has announced (at the annual JP Morgan Healthcare Conference) that its new machine, called the HiSeq X Ten is able to sequence whole human genomes in assembly line fashion at a pace of $1000 each. If the company's claims pan out, the machine will mark a major milestone in medical research technology.

Scientists who do have long hungered for a massive database filled with the complete genomes (and ) of millions of random people. Such a database would allow for spotting genetic patterns that would almost certainly lead to breakthroughs in very wide variety of . Sadly, such a database is still but a dream, as far too few people have had their genomes sequenced, which is due in large part, to the huge expense. For that reason, the science and medical community has established a watermark cost for sequencing an entire —at $1000. At that price-point, it is assumed that huge numbers of genomes would be sequenced, eventually leading to that elusive database. Now, it appears, that day might have come. The new machine by Illumina (which is actually a system of ten identical machines that cost $10 million each), its makers say, is able to partially sequence five human genomes in a single day, or 16 full and complete sequences over the course of three days.

To ensure accuracy, the HiSeq X Ten scans every single base pair 30 times. It does so courtesy of what's known as a flow cell, which holds DNA sample templates. The samples themselves are prepared using dyes that allow for precise photographing of the results which are then analyzed. Illumina reps report that the company has found a way to pack more templates into a smaller space, allowing for faster sequencing. The net result is a machine that can sequence genomes in a way that combines speed and accuracy in a way no other machine can, leading to its much lower price.

Researchers around the world are likely holding their collective breath upon hearing the announcement of the sequencer—other companies have made such claims before, but none have panned out. This time may be the charm, however, as the company says it has sold four systems thus far and will deliver them during the first quarter of this year.

Explore further: Big data: A method for obtaining large, phylogenomic data sets

More information: www.illumina.com/systems/hiseq… quencing-system.ilmn

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User comments : 8

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betterexists
1 / 5 (1) Jan 16, 2014
Ultrawealthy group should play a role in making that massive data available within 1-2 mos.

They should open a collective website where they would sponsor a portion of that fees with money repayable after 10 years in installments OR Even before that!

It will benefit Everyone. May be The Govts. should waive some tax for them for such philanthropy. They are going to get their money back, though!

Importance of the Data cannot be Argued.
betterexists
1 / 5 (1) Jan 16, 2014
Only 4 machine sets will be delivered in 3 months....Set of 10 each can sequence only about 37 in a Week
1950 /year/set.....not exact math
7800/4sets......Again, Not Exact Math
318 Million Americans. Tough Luck.
betterexists
1 / 5 (1) Jan 16, 2014
It means help from the Super Rich will NOT be needed for at least a decade because there are awful lot of people willing to shell down that kind of money themselves!

Only 4 machine sets will be delivered in 3 months....Set of 10 each can sequence only about 37 in a Week
1950 /year/set.....not exact math
7800/4sets......Again, Not Exact Math
318 Million Americans. Tough Luck.

ugosugo
5 / 5 (1) Jan 16, 2014
They forgot to mention that the machine costs 1 million $ and you have to buy at least 10 at a time!
Soylent_Grin
not rated yet Jan 16, 2014
What ever happened to the USB nanopore sequencing that could do it in hours?
Soundgardener
not rated yet Jan 16, 2014
Is this a mistake, because it implies that the entire system costs $100M:

"The new machine by Illumina (which is actually a system of ten identical machines that cost $10 million each)"

A capital cost of $100M, plus other equipment required, facilities, staff, power etc, and this just doesn't seem to be economic at $1000 per whole human genome sequenced. At a rate of 5.3 entire human genomes sequenced per day (16 per 3 days), it can churn out 1934 per year. At $1000 each, that's slightly under $2M in revenue.
betterexists
not rated yet Jan 16, 2014
Is this a mistake, because it implies that the entire system costs $100M:

"The new machine by Illumina (which is actually a system of ten identical machines that cost $10 million each)"

A capital cost of $100M, plus other equipment required, facilities, staff, power etc, and this just doesn't seem to be economic at $1000 per whole human genome sequenced. At a rate of 5.3 entire human genomes sequenced per day (16 per 3 days), it can churn out 1934 per year. At $1000 each, that's slightly under $2M in revenue.

That's why only a few purchased the machines. They may have to bring down the price of the machines.
Whydening Gyre
not rated yet Jan 16, 2014
Is this a mistake, because it implies that the entire system costs $100M:

"The new machine by Illumina (which is actually a system of ten identical machines that cost $10 million each)"

A capital cost of $100M, plus other equipment required, facilities, staff, power etc, and this just doesn't seem to be economic at $1000 per whole human genome sequenced. At a rate of 5.3 entire human genomes sequenced per day (16 per 3 days), it can churn out 1934 per year. At $1000 each, that's slightly under $2M in revenue.

That means a SUPER long ROI...