'Better detection' for Alzheimer's and cancers

Aug 26, 2013

A new chemical discovery will lead to better monitoring and treatment for cancers and degenerative diseases, according to latest research by scientists.

In a paper published today in ChemComm an international team of researchers from the Universities of Birmingham, Bath and the East China University of Science and Technology in Shanghai outline a new approach to detecting 'reactive oxygen' using fluorescence.

Reactive oxygen, which includes peroxides or , causes cell damage and degeneration in the body and its presence in high doses can be a sign of diseases such as Alzheimer's or cancers. The importance of reactive oxygen has led researchers to find new approaches for its quick and simple detection.

This latest research paves the way for new systems to detect changes in reactive which could help target interventions. Mapped using fluorescent imaging, the concentration of reactive oxygen in cells and tissue would light up which will help better understand and monitor disease development and intervention. Using fluorescence probes it will be possible to perform whole body imaging, making it is possible to monitor in situ tumour development in real-time.

Dr John Fossey from the School of Chemistry at the University of Birmingham said: 'This most recent project has taken the international CASE consortium in a different and exciting direction. Developing a new sensing model based on reactive oxygen has many useful applications in diagnosing and detecting disease.'

Professor Tony James from the University of Bath, commented: 'I am very excited by these new results which have pointed our research in an unexpected yet truly rewarding direction. This work uses 'simple' molecules which are capable of helping doctors understand and diagnose 'difficult'diseases.'

Explore further: Haunting tales in ship-wrecked silver

add to favorites email to friend print save as pdf

Related Stories

A designer enzyme for alternative energy

Jun 21, 2013

(Phys.org) —Imagine pulling energy out of thin air. Yi Lu and his colleagues are on that path, in a quest to find alternatives to fossil fuels. The team has designed an enzyme that can harvest the energy ...

Light dynamics for cancer treatment

May 03, 2012

Research is delving into refinement of a revolutionary cancer treatment, photodynamic therapy (PDT). Using light, reactive oxygen and photosensitisers linked to specially designed antibodies, scientists are on the threshold ...

Enzyme may be a key to Alzheimer's-related cell death

Oct 06, 2009

(PhysOrg.com) -- A Purdue University researcher has discovered that the amount of an enzyme present in neurons can affect the mechanism thought to cause cell death in Alzheimer's disease patients and may have ...

Recommended for you

New material steals oxygen from the air

18 hours ago

Researchers from the University of Southern Denmark have synthesized crystalline materials that can bind and store oxygen in high concentrations. Just one spoon of the substance is enough to absorb all the ...

Driving cancer cells to suicide

18 hours ago

Ludwig Maximilian University of Munich researchers report that a new class of chemical compounds makes cancer cells more sensitive to chemotherapeutic drugs. They have also pinpointed the relevant target ...

Neutral self-assembling peptide hydrogel

22 hours ago

Self-assembling peptides are characterized by a stable β-sheet structure and are known to undergo self-assembly into nanofibers that could further form a hydrogel. Self-assembling peptide hydrogels have ...

User comments : 0