Biology's drive toward engineering

Jun 05, 2013
Biology’s drive toward engineering
The basic tools of “synthetic biology” are falling into place to enable scientists to assemble biological parts with the same precision and predictability of engineers constructing bridges or engines. Credit: iStockphoto/Thinkstock

Biology is on the verge of getting its versions of the lever, wheel and axle, pulley and other basic machines that enable engineers to build almost any mechanical device, a new analysis has concluded. The viewpoint article on availability of this new toolkit—for engineering biological factories that can produce new biofuels, crops and chemicals, among others—appears in the journal ACS Synthetic Biology.

Kevin Munnelly, CEO of synthetic biology start-up Gen9, explains that people have been using basic genetic engineering for centuries to breed stronger oxen, faster horses and improved . In recent years, however, there have been great leaps forward in the field of "synthetic biology." Powered in part by advances in genome sequencing, chip-based processing and chemical innovations, that field is developing a solid engineering foundation of biological parts that can be assembled with the same precision and predictability of engineers constructing bridges or engines, and applied at the scale required for industrial manufacturing. Using synthetic biology, innovators across industries are building billion-dollar-plus markets for plants that churn out biofuels, create new textiles or yield crops that will thrive in any environment. They are also tackling data storage. For example, the entire contents of the could fit within a shot-glass of DNA.

In this viewpoint article, Munnelly describes the significant accomplishments that have shaped the synthetic biology landscape, as well as possible future innovations. Synthetic biology is already building its basic toolkit, with a switch and an oscillator, for instance, and scientists have stored 70 billion copies of a book in genetic material the size of a garden pea. On the horizon are drop-in genes, protein signaling pathways and other interchangeable parts for the emerging toolkit.

The article is titled "Engineering for the 21st Century: Synthetic Biology."

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More information: Engineering for the 21st Century: Synthetic Biology, ACS Synth. Biol., 2013, 2 (5), pp 213–215. DOI: 10.1021/sb400039g

Abstract
For years, scientists have hoped that biology would find its engineering counterpart – a series of principles that could be used as reliably as chemical engineering is for chemistry. Thanks to major advances in synthetic biology, those hopes may soon be realized.

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