Unlocking secrets of cell reproduction

May 23, 2013
Scientists unlock secrets of cell reproduction
Magnified yeast cells. Credit: Cancer Research UK

Research published in Open Biology today identifies, for the first time, nearly all the genes required for reproduction of a cell in a living organism.

Scientists from Cancer Research UK studied a set of of yeast in each of which a single gene had been deleted. Each strain was examined to see if cell reproduction or was changed and in this way all the genes involved in these processes were identified.

The researchers visually screened 4843 yeast mutants, each with a different gene deleted, to observe the effects on and formation. The genes investigated comprise 95.7% of total protein encoding genes. A total of 513 genes were identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Their results describe a near genome-wide set of genes required for the cell cycle and cell shape.

Dr Julie Sharp, Cancer Research UK's senior science information manager, said: "For the first time our researchers have created a complete picture of the genes that control cell growth and behaviour in , which could reveal more about how cancer starts and develops and highlight new ways to tackle the disease.

"Research like this will be central to the work at the Institute, a new super- laboratory in London headed by Professor Sir Paul Nurse [co-author of this paper], where scientists will tackle major diseases such as cancer using the very latest technologies."

Explore further: Two-armed control of ATR, a master regulator of the DNA damage checkpoint

More information: Hayles, J. et al. A genome-wide resource of cell cycle and cell shape genes of fission yeast, Open Biology. dx.doi.org/10.1098/rsob.130053

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