Microfluidic devices move from application to fundamental science

May 15, 2013
Microfluidic devices move from application to fundamental science
The secrets in a drop of water. Microfluidic devices are used to detect chemicals in small samples for health and security concerns. Now, this imaging technology is being applied to answer fundamental questions.

(Phys.org) —Just a few drops of liquid or a bit more is run past specialized sensors in microfluidic devices to detect chemicals of concern to doctors and security personnel. However, these devices are now being reinvented for use in scientific instruments to answer fundamental questions, according to a review written by scientists at Pacific Northwest National Laboratory and published in Microfluidics and Nanofluidics.

"This is one of the first reviews that report how microfluidics enable characterization of liquids," said Dr. Xiao-Ying Yu, PNNL, who led the review. "This is a unique paper in that it gives the perspective needed to understand molecular-level interactions with microfluidics."

From catalysts to , molecular-level interactions in liquids are of interest to scientists. allow scientists to obtain data by channeling small samples past or spectrometers. The devices hold the sample, and are then fitted into the instrument for analysis. This area of research is quickly growing, and the review included devices that worked at different pressures, including vacuums.

In reviewing recent technical breakthroughs, the team examined the one-of-a-kind microfluidic cell fabricated by Yu and her colleagues. This device, about the size of a large dessert brownie, allows for bimodal analysis or characterization by two different instruments without reconfiguring the device. Recent tests show the device is able to run for hours, providing high-quality images of the changing properties of the liquid surface.

"The device we invented and the review article take advantage of our expertise in microfluidics, imaging, and an understanding of the instruments," said Yu.

Explore further: New chip promising for tumor-targeting research

More information: Yu, X., Liu, B. and Yang, L. 2013. Imaging Liquids Using Microfluidic Cells. Microfluidics and Nanofluidics. Online. DOI: 10.1007/s10404-013-1199-4

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

New chip promising for tumor-targeting research

13 hours ago

(Phys.org) —Researchers have developed a chip capable of simulating a tumor's "microenvironment" and plan to use the new system to test the effectiveness of nanoparticles and drugs that target cancer.

New star-shaped molecule breakthrough

18 hours ago

(Phys.org) —Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created.

A refined approach to proteins at low resolution

Sep 19, 2014

Membrane proteins and large protein complexes are notoriously difficult to study with X-ray crystallography, not least because they are often very difficult, if not impossible, to crystallize, but also because ...

User comments : 0