Bioengineers create rubber-like material bearing micropatterns for stronger, more elastic hearts

April 29, 2013
Various microfabrication techniques were used to make highly elastic hydrogels with well-defined micropatterns. Credit: Ali Khademhosseini lab.

A team of bioengineers at Brigham and Women's Hospital (BWH) is the first to report creating artificial heart tissue that closely mimics the functions of natural heart tissue through the use of human-based materials. Their work will advance how clinicians treat the damaging effects caused by heart disease, the leading cause of death in the United States.

"Scientists and clinicians alike are eager for new approaches to creating artificial heart tissues that resemble the native tissues as much as possible, in terms of physical properties and function," said Nasim Annabi, PhD, BWH Renal Division, first study author. "Current biomaterials used to repair hearts after a heart attack and other cardiovascular events lack suitable functionality and strength. We are introducing an alternative that has the mechanical properties and functions of native heart tissue."

The study was published online on April 26, 2013 in Advanced Functional Materials.

Researchers made a micropatterned MeTro gel by placing the MeTro solution on a glass slide, and then using a mold and UV light to impress a micropattern on it. Credit: Ali Khademhosseini lab.

The researchers created MeTro gel—an advanced rubber-like material made from tropoelastin, the protein in human tissues that makes them elastic. The gel was then combined with to generate gels containing well-defined micropatterns for high elasticity.

The researchers then used these highly elastic micropatterned gels to create heart tissue that contained beating heart muscle cells.

"The micropatterned gel provides elastic mechanical support of natural as demonstrated by its ability to promote attachment, spreading, alignment, function and communication of ," said Annabi.

These images show heart muscle cells aligning and stretching on the surface of micropatterned gels. Credit: Ali Khademhosseini lab.

The researchers state that MeTro gel will provide a model for future studies on how behave. Moreover, the work lays the foundation for creating more elaborate 3D versions of that will contain vascular networks.

"This can be achieved by assembling tandem layers of micropatterned MeTro gels seeded with heart muscles cells in different layers," said Ali Khademhosseini, PhD, BWH Division of Biomedical Engineering, co-senior study author. "As we continue to move forward with finding better ways to mend a broken heart, we hope the biomaterials we engineer will allow us to successfully address the limitations of current artificial tissues."

Explore further: Nanomaterials key to developing stronger artificial hearts

Related Stories

Nanomaterials key to developing stronger artificial hearts

January 31, 2013

On January 30, 2013 ACS Nano published a study by Ali Khademhosseini, PhD, MASc, Brigham and Women's Hospital Division of Biomedical Engineering, detailing the creation of innovative cardiac patches that utilize nanotechnology ...

Recommended for you

A new form of real gold, almost as light as air

November 25, 2015

Researchers at ETH Zurich have created a new type of foam made of real gold. It is the lightest form ever produced of the precious metal: a thousand times lighter than its conventional form and yet it is nearly impossible ...

New 'self-healing' gel makes electronics more flexible

November 25, 2015

Researchers in the Cockrell School of Engineering at The University of Texas at Austin have developed a first-of-its-kind self-healing gel that repairs and connects electronic circuits, creating opportunities to advance the ...

Getting under the skin of a medieval mystery

November 23, 2015

A simple PVC eraser has helped an international team of scientists led by bioarchaeologists at the University of York to resolve the mystery surrounding the tissue-thin parchment used by medieval scribes to produce the first ...

Atom-sized craters make a catalyst much more active

November 24, 2015

Bombarding and stretching an important industrial catalyst opens up tiny holes on its surface where atoms can attach and react, greatly increasing its activity as a promoter of chemical reactions, according to a study by ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.