ALBA Synchrotron used for first time as microscope to determine protein structure

Apr 10, 2013
ALBA Synchrotron.

A team led by David Reverter, a researcher at the Institute of Biotechnology and Biomedicine (IBB) of the UAB, has determined for the first time the three-dimensional structure of a protein pair: LC8 and Nek9. Depending on whether or not they bind, Nek9 ensures that the chromosomes group and separate correctly during cell division.

By analysing the 3D structure, these scientists have discovered a new mechanism that interferes with the and therefore also contributes to the correct regulation of cell division and other cell processes. The discovery could have implications for the study of diseases related to cell division processes, like cancer.

The 3D structure, published in the Journal of Biological Chemistry, was obtained from data collected by the XALOC of the ALBA Synchrotron. It is the first time that the crystal structure of a protein has been obtained by using this synchrotron and published in a scientific journal.

Explore further: New tool identifies therapeutic proteins in a 'snap'

More information: Gallego, P. et al. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation, Journal of Biological Chemistry. March 12, 2013, doi: 10.1074/jbc.M113.459149

add to favorites email to friend print save as pdf

Related Stories

New discoveries in cell aging

Jan 23, 2012

A group of researchers led by the Institute of Biotechnology and Biomedicine (IBB) and Universitat Autònoma de Barcelona (UAB) have achieved to quantify with precision the effect of protein aggregation on cell aging ...

New key mechanism in cell division discovered

May 18, 2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have identified the mechanism by which protein Zds1 regulates a key function in mitosis, the process that occurs immediately before cell division. The ...

Recommended for you

New tool identifies therapeutic proteins in a 'snap'

Aug 21, 2014

(Phys.org) —In human and bacterial cells, glycosylation – the chemical process of attaching complex sugar molecules to proteins – is as fundamental as it gets, affecting every biological mechanism from cell signaling ...

Treating pain by blocking the 'chili-pepper receptor'

Aug 20, 2014

Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others. Scientists exploring the chili pepper's effect are using their findings to develop a new drug ...

Moving single cells around—accurately and cheaply

Aug 19, 2014

Scientists at the Houston Methodist Research Institute have figured out how to pick up and transfer single cells using a pipette—a common laboratory tool that's been tweaked slightly. They describe this ...

The difficult question of Clostridium difficile

Aug 19, 2014

The bacterium Clostridium difficile causes antibiotic-related diarrhoea and is a growing problem in the hospital environment and elsewhere in the community. Understanding how the microbe colonises the hu ...

User comments : 0