Researchers discover mechanism that regulates steroid hormone production in Drosophila

Mar 07, 2013
Bantam mutant animals (right) show reduced body size as a result of abnormally high steroid hormone levels. Credit: © M. Milán lab, IRB Barcelona. Author: Laura Boulan

Looking at the transformation of a fly larva into a pupa may help researchers to understand the molecular mechanisms that trigger puberty. A study conducted on the fruit fly, Drosophila melanogaster, by scientists at the Institute for Research in Biomedicine (IRB Barcelona) led by ICREA research professor Marco Milán, identifies an miRNA as key to the relationship between hormones that control growth and sexual maturity.

According to Milán, "accelerated growth or obesity can provoke premature puberty in humans, harming their development – and this is a growing problem in Western societies. Today, physicians know very little about the molecular mechanisms behind premature puberty, and Drosophila is providing us with our first hints." has published the study today online.

The study, whose first author, Laura Boulan, is a french PhD student within the "la Caixa" International PhD Programme at IRB Barcelona, pulled apart the phases of development in the fly to reveal a delicate dialogue between growth and maturity, and found that it is regulated by the activity of an called bantam. The team discovered that insulin, a hormone involved in metabolism and growth, reduces the levels of bantam present in the cells. Reduced levels of bantam lead to an increase in levels. "This increase in steroid hormones causes growth to stop," says Milán. Though the relationship between metabolism, growth and puberty is already known, this study has identified for the first time the molecular mechanism that determines this relationship and has pinpointed bantam as a key mediator in the dialogue between the hormones involved.

The fly prothoracic gland (in green) produces steroid hormones. Credit: M. Milán lab, IRB Barcelona. Author: Laura Boulan Credit: © M. Milán lab, IRB Barcelona. Author: Laura Boulan

These findings may be relevant to if elements homologous to those found in flies can be identified in people. "Premature slows down growth, preventing adults from developing properly," says Boulan. Despite the differences between the fruit fly and humans, this study represents an important step forward. The high degree of genetic similarity and the conservation of many between the two species allow researchers to model many complex phenomena in flies, or worms, and then look to see if they correspond to what they see in other more complex models, including humans.

"By beginning to identify these elements in Drosophila, researchers will be able to make much faster progress in their efforts to discover new drugs to prevent and treat premature puberty," concludes Milán.

Explore further: Genomes of malaria-carrying mosquitoes sequenced

More information: Current Biology (2013). doi: 10.1016/j.cub.2013.01.072

add to favorites email to friend print save as pdf

Related Stories

Control gene for developmental timing discovered

Sep 28, 2011

University of Alberta researchers have identified a key regulator that controls the speed of development in the fruit fly. When the researchers blocked the function of this regulator, animals sped up their rate of development ...

Fruit Flies, Death, and Immunity

Mar 28, 2007

University of Arkansas scientists have found an important mechanism that regulates the destruction of larval fruit fly salivary glands that could point the way to understanding programmed cell death in the human immune system.

A new system for collaboration in cell communication

Jun 26, 2007

Investigators from the Institute of Research in Biomedicine (IRB Barcelona) have identified a new signalling mechanism among cells in the fruit fly, Drosophila melanogaster. The researchers found that two independent groups ...

Recommended for you

Genomes of malaria-carrying mosquitoes sequenced

19 hours ago

Nora Besansky, O'Hara Professor of Biological Sciences at the University of Notre Dame and a member of the University's Eck Institute for Global Health, has led an international team of scientists in sequencing ...

How calcium regulates mitochondrial carrier proteins

Nov 26, 2014

Mitochondrial carriers are a family of proteins that play the key role of transporting a chemically diverse range of molecules across the inner mitochondrial membrane. Mitochondrial aspartate/glutamate carriers are part of ...

Team conducts unprecedented analysis of microbial ecosystem

Nov 26, 2014

An international team of scientists from the Translational Genomics Research Institute (TGen) and The Luxembourg Centre for Systems Biomedicine (LCSB) have completed a first-of-its-kind microbial analysis of a biological ...

Students create microbe to weaken superbug

Nov 25, 2014

A team of undergraduate students from the University of Waterloo have designed a synthetic organism that may one day help doctors treat MRSA, an antibiotic-resistant superbug.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.