Researchers design potential blood thinner that also unmasks cancer cells

Dec 06, 2012 by Lindsay Taylor Key
Researchers design potential blood thinner that also unmasks cancer cells
Rafael Davalos, Pavlos Vlachos, Daniel Capelluto, and Carla Finkielstein designed small molecules modeled after a naturally occurring protein that may have potential to be developed into an efficient, safer blood thinner.

(—Virginia Tech researchers have discovered a potential way to create a new kind of anticoagulant drug commonly called a blood thinner. 

Blood thinners are important for people with or who are at risk for heart attacks and strokes—leading causes of death in the United States.

But prescription blood thinners have long-lasting effects in the body and may cause unwanted side effects, including bleeding, according to Daniel Capelluto and Carla Finkielstein, associate professors of biological sciences in the College of Science who are affiliated with the Fralin Life Science Institute and the Virginia Tech Center for .

Working with Rafael Davalos, an associate professor of biomedical engineering, and Pavlos Vlachos, a professor of mechanical engineering, both in the College of Engineering, the scientists created a microfluidic device that emulates flow conditions within a blood vessel to explore the therapeutic role of a naturally occurring protein called Disabled-2, which ultimately prevents blood from clotting.

From there, the scientists designed small molecules modeled after Disabled-2 that may have the potential to be developed into an efficient, safer blood thinner.

The discovery is reported in the Nov. 2, issue of the .

Cardiovascular disease is the leading cause of death in the United States and stroke is the fourth most common, according to the American Heart Association.

There are several advantages of the proposed new drug, researchers say, including its multi-targeted action, specificity, and rapid clearance from the blood stream after its therapeutic action is completed.

Because it is delivered via nanoparticles, it bypasses the immune system and causes no secondary effects in the patient—characteristics that may impact cancer treatment.

"When you have a metastatic process and are moving through your bloodstream, the doesn't seem to recognize them as bad cells. This is largely due to platelets that coat the cancer cells," Finkielstein said. "Our drug exposes the cancer cells to the immune system by essentially unmasking them. Thus, the drug can be used along with other technologies for ."

The drug is linked to two patents owned by the researchers and Virginia Tech.  Research was funded by the and a Fralin Life Science Institute seed grant.  Investigators are also associated with the Multiscale Bio-Engineered Devices and Systems group within the Institute for Critical Technology and Applied Science.

Explore further: Researchers use neutron scattering and supercomputing to study shape of a protein involved in cancer

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1 / 5 (1) Dec 07, 2012
In regards to the cancer aspect of this article, they're barking up the wrong tree. The cure for cancer is already known: It is called cannabis, and it is illegal, thanks to stupid governments. Nevertheless, do yourself a favor and look into "Rick Simpson oil" and the first-hand testimonials of its users who overcame cancer called "incurable" by mainstream medicine (another stupid aspect of our society). These scientists mentioned in the article will never be able to develop a cancer fighting drug because there will be obstacles thrown in front of their research efforts. In the rare event that they succeed, that drug will also be made illegal by stupid governments, and/or they will be put on "quack" lists.

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