Nanotechnology allows scientists to capture and preserve cancer cells circulating in the bloodstream

Dec 17, 2012
A new-generation nano-platform capable of capturing circulating tumor cells and releasing them at reduced temperature. Credit: RIKEN

Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream. This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body.

The device provides a convenient and non-invasive alternative to biopsy, the current method for diagnosis of metastatic cancer. It could enable doctors to detect tumor cells that circulate in cancer patients' blood well before they subsequently colonize as tumors in other organs. The device also enables researchers to keep the tumor cells alive and subsequently study them.

The device was developed by a team led by Hsiao-hua Yu from the RIKEN Advanced Science Institute in Japan and Hsian-Rong Tseng from the Department of Molecular and at the University of California Los Angeles, in research published online today in the journal Advanced Materials.

Similar cell-capture devices have been reported but this technology is unique in that it is capable of catching the tumor cells with great efficiency and releasing them with great . Blood is passed through the device like a filter that contains a molecule capable of adhering to tumor cells like Velcro and separating them with efficiency ranging from 40% to 70%. The are retained by tiny temperature-responsive inside the device. At 37 degrees Celsius, these polymer brushes stick to the tumor cells, but when cooled to 4 degrees Celsius, they release them, allowing scientists to examine the cells.

"Until now, most devices have demonstrated the ability to capture with high efficiency. However, it is equally important to release these captured cells, to preserve and study them in order to obtain insightful information about them. This is the big difference with our device." Explains Hsiao-hua Yu, who led the team that developed the technique to coat the device with polymer brushes.

Explore further: Nanocontainers for nanocargo: Delivering genes and proteins for cellular imaging, genetic medicine and cancer therapy

More information: Shuang Hou, Haichao Zhao, Libo Zhao, Qinglin Shen, Kevin S. Wei, Daniel Y. Suh, Aiko Nakao, Bin Xiong, Shyh-Chyang Luo,Hsian-Rong Tseng,Hsiao-hua Yu "Capture and Stimulated Release of Circulating Tumor Cells on Polymer-Grafted Silicon Nanostructures." Advanced Materials, 2012.

add to favorites email to friend print save as pdf

Related Stories

Catching cancer with carbon nanotubes

Mar 28, 2011

A Harvard bioengineer and an MIT aeronautical engineer have created a new device that can detect single cancer cells in a blood sample, potentially allowing doctors to quickly determine whether cancer has ...

Recommended for you

Twisted graphene chills out

Sep 17, 2014

(Phys.org) —When two sheets of graphene are stacked in a special way, it is possible to cool down the graphene with a laser instead of heating it up, University of Manchester researchers have shown.

Researchers use liquid inks to create better solar cells

Sep 17, 2014

(Phys.org) —The basic function of solar cells is to harvest sunlight and turn it into electricity. Thus, it is critically important that the film that collects the light on the surface of the cell is designed ...

User comments : 0