Yeast models of cell death and survival mechanisms

Oct 19, 2012
Yeast models of cell death and survival mechanisms
Credit: Thinkstock

European scientists investigated differences in the genomes of various distantly-related yeast and their effects on cell survival. Results may provide insight into cell death induced by free radicals.

Most of us have heard of the health benefits of nutritional sources high in antioxidants such as vitamin C, vitamin E and beta-carotene. Antioxidants remove oxidants and , highly reactive molecules produced naturally by the body or introduced to the body by toxins such as tobacco smoke or ultraviolet (UV) light.

Oxidative stress induced by high levels of such reactive (ROS) can induce changes in the cell cycle and DNA. It has also been linked to a variety of disease processes and ageing.

sought to gain insight into the relationship between oxidative stress and cell cycle regulation with EU funding of the Oxicellcycle project. Scientists chose the powerful yet simple single-cell fission yeast model. Fission yeast are characterised by cell division and replication mechanisms similar to those of multi-cellular organisms.

In particular, they studied mechanisms (barriers preventing two individuals of different species from producing offspring) across different wild forms of specific fission yeast, Schizosaccharomyces pombe (S. pombe). Investigators applied a wide range of genetics techniques to evaluate genome-based effects on spore survival.

Preliminary studies identifying genetic differences among distantly related strains of S. pombe may eventually shed light on certain cell cycle-regulated genes and their relationship to .

Explore further: Researchers discover new mechanism of DNA repair

Related Stories

New genetic switch allows cells to thrive in low oxygen

Oct 28, 2011

(PhysOrg.com) -- Johns Hopkins scientists have revealed a new way that cells respond to the challenge of low oxygen. A report on the discovery about how the fission yeast Schizosaccharomyces pombe regulates ...

Recommended for you

Researchers discover new mechanism of DNA repair

Jul 03, 2015

The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed.

Stopping Candida in its tracks

Jul 03, 2015

Scientists are one step closer to understanding how a normally harmless fungus changes to become a deadly infectious agent.

New technique maps elusive chemical markers on proteins

Jul 02, 2015

Unveiling how the 20,000 or so proteins in the human body work—and malfunction—is the key to understanding much of health and disease. Now, Salk researchers developed a new technique that allows scientists ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.