A vision to help: Engineering students design bare-bones microscope for clinics in developing world

Jun 06, 2012
Kyle Stewart, left, and Reggie Ballesteros at work on a prototype for a three-in-one microscope, which will be field tested in Mozambique this summer.

(Phys.org) -- Students at the Jacobs School of Engineering are working to develop a cheaper, lighter, multi-function microscope that could be used in clinics in developing countries. Their prototype will be flown to Mozambique this summer and field tested at Universidade Eduardo Mondlane in the country’s capital, Maputo.

Their goal is to design a three-in-one device that can be used as a brightfield and fluorescent as well as a spectrophotometer to examine everything from blood cells to bacteria. Traditional 2-in-one microscopes can cost more than $50,000—and none have historically been equipped for spectroscopy as well. “We are aiming for under $500,” said Dr. Eliah Aronoff-Spencer, a physician scientist in UC San Diego’s infectious disease department and the project’s sponsor. The low-cost microscope has another advantage: it’s run by and sends the images it captures to a laptop or iPad so physicians can start using and sharing data right away.

Dr. Aronoff-Spencer is one of the physicians partnering with Mozambique doctors to improve research, training and technology in the country as part of a five-year, $12.5-million award from the U.S. Medical Education Partnership Initiative. Mozambique badly needs medical equipment, the UC San Diego doctor explained. The country of 20 million residents, and less than 1,000 doctors, only has two functioning medical schools and is building two more.

Engineering undergraduates said building the microscope is the best learning experience they’ve had on campus.

“It really brings home all the issues we talk about in class,” said Kyle Stewart, one of the four mechanical engineering seniors working on the device. “All that becomes real when you work on this project.”

Stewart said he had a great internship last summer. “But I didn’t learn anywhere near what I’ve learned from this.”

The prototype's design displayed on a laptop.

The are now on their third prototype for the microscope and estimate there will be at least three more before the quarter is over. The goal is a 6 by 6 by 13 inches box with different trays that allow for different imaging techniques.

Their decision to keep slide trays stationary, and the optics mobile, is what made the device possible, said Leonardo Costello, one of the four students working on the project. In a traditional microscope, it’s the other way around.

Images obtained with the new low-cost microscope. Left: blood cells. Right: a stained blood sample. 

The device uses a CMOS chip in the imaging unit and a full CCD chip to take spectrometry pictures in any position. The ultimate goal is to image objects down to 0.5 microns in diameter. A hair’s breadth is about 100 microns.

The project has become a full-time job for the students, who have been spending eight to 14 hours a day, five days a week, in the lab at EBU II. “It’s to the point where people are surprised if they don’t see us in here,” Stewart joked.

All say they knew they wanted to be engineers from a young age. Stewart has played with LEGOs since he was 6 years old and learned how to use LEGO Mindstorms as part of a middle school gifted and talented students program. “I’ve always liked making things, so everything pointed to engineering,” he said. He is going to graduate school at San Diego State University.

Reginald Ballesteros is following in the footsteps of his father, who is a civil engineer. He will be interning at Goodrich Aerostructures this summer. In the fall, he will be going to Santa Clara University for a master’s degree in mechatronics.

Costello’s father was a general contractor. Costello, who was home schooled until he came to UC San Diego, often got to spend time with him on the job. The younger Costello also spent a lot of time in the family’s garage, building various creations. He recently accepted a job at North American Repower, a company that specializes in heavy-duty natural gas engine technology.

Sean Patno is responsible for much of the user interface and software aspects of the project. He will probably land a job as a software engineer after he graduates, he said.

Dr. Aronoff-Spencer said he has been impressed by the students’ work—and by their work ethic.

“They are working harder than any students I’ve ever seen,” he said.

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dschlink
not rated yet Jun 06, 2012
Moving the programming from the device to an inexpensive laptop is a smart move.

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