New plaster enhances wound healing

May 31, 2012 By Maja Schaffner
New plaster enhances wound healing
An interdisciplinary research team at ETH Zurich consisting of engineers and biologists has developed a specialized silicone plaster with tiny parallel grooves on its surface. Credit: A. Marmaras / ETH Zurich

( -- Swiss researchers at ETH Zurich have developed a plaster that accelerates wound healing and is easily removed from the wound at any time. Burn victims in particular may profit from this invention in the future.

When one cuts a finger, it is usually sufficient to apply some and a simple . The cut will heal in a few days. However, some wounds can take much longer to heal. Burns are a notable example.

Wound healing is dependent on the migration of certain to the wounded region. These so called fibroblasts normally migrate from the wound edges in a more or less unordered fashion, building new tissue on their way. If migration is impaired, result. In bigger wounds, fibroblasts must sometimes travel large distances to enable the creation of new skin – and this takes time.

ETH-Researchers in the group of Dr. Vartan Kurtcuoglu at the Laboratory of Thermodynamics in Emerging Technologies under the leadership of Prof. Dimos Poulikakos have developed a new method to guide fibroblasts quickly and efficiently to where they are needed in the healing process, namely from the edges of a wound to its center. As a result, wound healing is accelerated.

A plaster with a special surface

The interdisciplinary research team consisting of engineers and biologists has developed a specialized silicone plaster. This plaster has many tiny parallel grooves on its surface. In a cell culture experiment, a cell layer was wounded by scratching. When the researchers applied the plaster with its grooves parallel to the wound edges (against the direction of wound healing), the scratch healed as fast as a wound under a plaster without grooves. However, when they placed the grooves perpendicular to the wound edges (in the direction of ), they could observe under the microscope that the wound closed faster. The doctoral student Anastasios Marmaras could thus show that this novel plaster does indeed speed up the healing process.

Fibroblasts follow the direction of the grooves

The researchers could demonstrate that the fibroblasts migrated along the grooves of the new plaster. They therefore hypothesize that these cells, which are much larger than the grooves, chose the path of least resistance by following them. Moving across the grooves would cause more friction than traveling along them.

The grooves do not necessarily have to be arranged in a parallel manner, added Dr. Aldo Ferrari, the lead biologist in the team. Radial arrangement would also be possible, for example to close circular wounds.

Fibroblasts are in direct contact with the plaster, but do not connect to it. Instead, they are guided in purely mechanical fashion by the grooves. Consequently, the plaster can be removed at any time without tearing of cells or tissue. This is completely new, says Vartan Kurtcuoglu. In earlier studies researchers placed cells on materials to which these could adhere. While this did guide the fibroblasts to the wound center, the plaster could not be removed after the healing process was completed.

Practical application is foreseen

So far the ETH-Researchers have tested their new plaster only on single-layer cell cultures. The next goal will be in vivo experiments with which the scientists aim to verify that the method also works on animals or humans.

They see the primary application of the plaster in the treatment of . It is hoped that large will also heal significantly faster with this patch and that the organized migration of fibroblasts will reduce scars.

The application and commercialization of the new plaster with the specialized surface appears promising: A patent application for the method has been submitted. According to Dr. Stefan Lux of the ETH-Transfer office, who establishes contacts with companies, interest from industry has already been expressed.

Explore further: Genes involved in wound healing identified

More information: A. Marmaras, et al. Topography-mediated apical guidance in epidermal wound healing. Soft Matter, 2012, DOI: 10.1039/C2SM00030J

Related Stories

Artificial skin system can heal wounds

December 20, 2007

A new study in Artificial Organs tested the effects of a wound dressing created with hair follicular cells. The findings reveal that skin substitutes using living hair cells can increase wound healing.

Printed cells to treat burn victims

April 12, 2010

( -- A medical device that works rather like an inkjet printer is being developed in the US to heal burns and other wounds by "printing" skin cells directly onto the wound. The device, called a bioprinter, may ...

Infections detected by new dressing

November 2, 2010

Wounds have to be regularly checked, to make sure any complications in the healing process are detected at an early stage. A new material will make it possible to check wounds without changing the dressing: If an infection ...

Recommended for you

A new form of real gold, almost as light as air

November 25, 2015

Researchers at ETH Zurich have created a new type of foam made of real gold. It is the lightest form ever produced of the precious metal: a thousand times lighter than its conventional form and yet it is nearly impossible ...

Getting under the skin of a medieval mystery

November 23, 2015

A simple PVC eraser has helped an international team of scientists led by bioarchaeologists at the University of York to resolve the mystery surrounding the tissue-thin parchment used by medieval scribes to produce the first ...

Moonlighting molecules: Finding new uses for old enzymes

November 27, 2015

A collaboration between the University of Cambridge and MedImmune, the global biologics research and development arm of AstraZeneca, has led researchers to identify a potentially significant new application for a well-known ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.