Manufacturing genes to attack flu virus

May 27, 2012
An international research team has manufactured a new protein that can combat deadly flu epidemics. Credit: MSU photographer, Kurt Stepnitz

An international research team has manufactured a new protein that can combat deadly flu epidemics.

The paper, featured on the cover of the current issue of Nature Biotechnology, demonstrates ways to use manufactured genes as antivirals, which disable key functions of the , said Tim Whitehead, assistant professor of chemical engineering and materials science at Michigan State University.

"Our most potent design has proven effective on the vulnerable sites on many viruses, including several H1N1 (Spanish flu, ) and H5N1 (Avian flu) subtypes," said Whitehead, the paper's co-lead author. "These new therapeutics are urgently needed, so we were especially pleased to see that it neutralizes H1N1 viruses with potency."

From its earlier research, the team used computer-aided design to engineer proteins that targeted vulnerable sites on the highly adaptable virus. From there, researchers optimized their designer proteins by comprehensively mapping the mutations that gave the proteins a strong advantage when attacking the viruses' targeted areas.

The team improved their proteins through a process called "DNA deep sequencing." This allowed Whitehead and his colleagues to simultaneously sequence millions of variants of their manufactured proteins, identify and keep the beneficial mutations and optimize the proteins' performance.

"By taking only the best mutations, we can reprogram our proteins to burrow into viruses at key locations and render them harmless," he said. "Our work demonstrates a new approach to construct , which we hope will spur development of new by the biopharmaceutical industry."

This research also laid the groundwork for future treatments of all flu viruses as well as other diseases such as smallpox, Whitehead added.

Whitehead's co-authors included researchers from the University of Washington, the Scripps Research Institute (La Jolla, Calif.), Naval Health Research Center (San Diego) and the Weizmann Institute of Science (Rehovot, Israel).

The research was funded by Defense Research Projects Agency, the Defense Threat Reduction Agency, the National Institutes of Health, the National Institute of Allergy and Infectious Diseases and the National Institute of General Medical Sciences.

Explore further: Researcher developing wheat that does not sprout when exposed to wet harvest conditions

Related Stories

Pandemic mutations in bird flu revealed

Jul 09, 2008

Scientists have discovered how bird flu adapts in patients, offering a new way to monitor the disease and prevent a pandemic, according to research published in the August issue of the Journal of General Virology. Highly ...

Recommended for you

Woolly mammoth genome sequencer at UWA

12 minutes ago

How can a giant woolly mammoth which lived at least 200,000 years ago help to save the Tasmanian Devil from extinction? The answer lies in DNA, the carrier of genetic information.

Battling superbugs with gene-editing system

18 hours ago

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, infect ...

For legume plants, a new route from shoot to root

Sep 19, 2014

A new study shows that legume plants regulate their symbiotic relationship with soil bacteria by using cytokinins—signaling molecules— that are transmitted through the plant structure from leaves into ...

User comments : 0