Scientists discover new fat over lunch

Apr 09, 2012

Uncovering new fats, or lipids, with links to diseases in the human lens is as easy as taking a lunch break, according to chemists from the ARC Centre of Excellence for Free Radical Chemistry and Biotechnology at the University of Wollongong.

The research, conducted by Associate Professor Stephen Blanksby and his PhD student Shane Ellis, used ozone naturally present in laboratory air to find previously unknown lipids in the human lens. Their work will be featured as a hot article in the upcoming edition of the scientific journal, Analyst.

“My lunch breaks are never unproductive,” says Shane Ellis. “If I leave the human lens samples on the bench while I am at lunch, the background in the lab takes care of the reaction with the lipids. Afterwards I analyse the products from the reaction, and determine the structure of the lipids I have in my lens sample.” This builds on the group’s previous work showing that dramatic changes in the composition of the human lens occur as we age. These changes are associated with the onset of presbyopia, a condition where the eye loses its ability to focus on close objects.

“Revealing the molecular structure of lipids will help us understand their role in disease and provide future treatment options. We hope our work will provide scientists with a convenient tool to do this using nothing but air: a reagent every lab can afford,” says Associate Professor Blanksby.

Using a combination of two methods called desorption electrospray ionisation mass spectrometry (DESI) and thin layer chromatography (TLC) that the group combined specifically for these experiments, lipids can be characterised in one simple analysis, a significant improvement on older methods.

“Our method allows for reliable lipid identification in any complex biological sample. It has the potential to contribute enormously to what we know about lipids in human tissue and it is almost as simple as going out for a pub lunch!” says Associate Professor Blanksby.

Explore further: Skin patch could replace the syringe for disease diagnosis

Provided by University of Wollongong

5 /5 (3 votes)
add to favorites email to friend print save as pdf

Related Stories

Focus on fats

Oct 12, 2011

Almost everyone knows that fats are the culprits in expanding waistlines and killer diseases, but scientific understanding of the roles of "lipids" -- fats and oils -- inside cells in the body got short shrift until launch ...

Natural killers help fight human disease

Nov 28, 2011

(Medical Xpress) -- Researchers from The Australian National University have discovered a new type of cell which boosts the human body’s ability to fight off infections and life-threatening diseases.

New route to map brain fat

May 04, 2011

Mapping the fat distribution of the healthy human brain is a key step in understanding neurological diseases, in general, and the neurodegeneration that accompanies Alzheimer's disease in particular. Antonio Veloso and colleagues, ...

Recommended for you

Amino acids key to new gold leaching process

Oct 24, 2014

Curtin University scientists have developed a gold and copper extraction process using an amino acid–hydrogen peroxide system, which could provide an environmentally friendly and cheaper alternative to ...

Researchers create designer 'barrel' proteins

Oct 23, 2014

Proteins are long linear molecules that fold up to form well-defined 3D shapes. These 3D molecular architectures are essential for biological functions such as the elasticity of skin, the digestion of food, ...

User comments : 0