First proof of ferroelectricity in simplest amino acid

April 19, 2012
ORNL researchers detected for the first time ferroelectric domains (seen as red stripes) in the simplest known amino acid -- glycine. Credit: ORNL

The boundary between electronics and biology is blurring with the first detection by researchers at Department of Energy's Oak Ridge National Laboratory of ferroelectric properties in an amino acid called glycine.

A multi-institutional research team led by Andrei Kholkin of the University of Aveiro, Portugal, used a combination of experiments and modeling to identify and explain the presence of ferroelectricity, a property where materials switch their polarization when an electric field is applied, in the simplest known amino acid—glycine.

"The discovery of ferroelectricity opens new pathways to novel classes of bioelectronic logic and memory devices, where polarization switching is used to record and retrieve information in the form of ferroelectric domains," said coauthor and senior scientist at ORNL's Center for Nanophase Materials Sciences (CNMS) Sergei Kalinin.

Although certain biological molecules like glycine are known to be piezoelectric, a phenomenon in which materials respond to pressure by producing electricity, ferroelectricity is relatively rare in the realm of . Thus, scientists are still unclear about the potential applications of ferroelectric biomaterials.

"This research helps paves the way toward building memory devices made of molecules that already exist in our bodies," Kholkin said.

For example, making use of the ability to switch through tiny electric fields may help build nanorobots that can swim through human blood. Kalinin cautions that such nanotechnology is still a long way in the future.

"Clearly there is a very long road from studying electromechanical coupling on the molecular level to making a nanomotor that can flow through blood," Kalinin said. "But unless you have a way to make this motor and study it, there will be no second and third steps. Our method can offer an option for quantitative and reproducible study of this electromechanical conversion."

The study, published in Advanced Functional Materials, builds on previous research at ORNL's CNMS, where Kalinin and others are developing new tools such as the piezoresponse force microscopy used in the experimental study of glycine.

"It turns out that piezoresponse force microsopy is perfectly suited to observe the fine details in biological systems at the nanoscale," Kalinin said. "With this type of microscopy, you gain the capability to study electromechanical motion on the level of a single molecule or small number of molecular assemblies. This scale is exactly where interesting things can happen."

Kholkin's lab grew the crystalline samples of glycine that were studied by his team and by the ORNL microscopy group. In addition to the experimental measurements, the team's theorists verified the ferroelectricity with molecular dynamics simulations that explained the mechanisms behind the observed behavior.

Explore further: Electromechanical Imaging of Butterfly Wings and Other Biological Tissue

More information: Adv. Funct. Mater.. doi: 10.1002/adfm.201103011

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4 comments

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ragarain
1 / 5 (1) Apr 19, 2012
"Clearly there is a very long road from studying electromechanical coupling on the molecular level to making a nanomotor that can flow through blood," Kalinin said. "But unless you have a way to make this motor and study it, there will be no second and third steps."
A2G
1.3 / 5 (4) Apr 19, 2012
Really interesting research and far more important than this article leads the reader to think..

Maybe their are other ways of fixing problems in the human body than drugs? Perhaps there is an electrical based method that would be far superior without using drugs.
Sean_W
1 / 5 (1) Apr 19, 2012
Could there be any examples where enzymes have evolved to utilize the ferroelectric property?
Mike_Massen
1 / 5 (2) Apr 20, 2012
A2G probably got hung up on the negative connotation of the word 'drug'
..Maybe there are other ways of fixing problems in the human body than drugs? Perhaps there is an electrical based method that would be far superior without using drugs.
Depends on how you interpret the word 'drug', from the perspective of foods which are replete with natural chemicals which are active in the body one could validly say these are drugs. ie. They function, relative mass can be easily changed to enhance or diminish any number of properties.

Chemicals/drugs already use electrical systems by virtue of bonding and signalling which is electrical at molecular level.
Eg. Natural Superoxide-Dismutase has Zn and Cu, source of potential ?

In order to deliver an electrical (macro) method, you need electrodes and a means to target intended receptors, many natural & synthetic drugs are efficient at this.

The permutation space is ~10^60 for carbon compounds, many chances to create good drugs.

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