Arctic evolution leads to salmonella vaccine

Mar 05, 2012

Bacteria harvested from the frigid waters of the Arctic could be the key to a new type of temperature-sensitive vaccine. University of Victoria microbiology researcher Dr. Francis Nano has received Genome BC Proof-of-Concept funding to use that bacteria to develop a vaccine that will immunize chickens against Salmonella enterica.

Vaccinating animals against a variety of diseases has begun to play an important role in ensuring global food security, especially as the overuse of has led to a rise in . infection, or salmonellosis, is one of the most common food-borne illnesses in the world. Approximately 10,000 cases of are reported by Canadians each year, and many more cases go unreported. Internationally, millions of deaths are linked to this infection.

Nano’s lab at UVic will replace an essential gene in a Salmonella bacterium with a gene from an Arctic bacterium. This process will create a modified bacterium that will no longer be able to survive in a warm environment such as the tissue of a warm-blooded animal. When used as a vaccine this temperature-sensitive bacterium will immunize and protect the recipient from future infection.

“Using Arctic genes, we can create bacterial pathogens that behave like vaccines, much like the many temperature-sensitive viruses that are used as vaccines,” says Nano. “We can apply this same approach to develop new vaccines against many diseases of humans and animals.”

Nano and his collaborators are using this technology to produce a cost-effective vaccine that will reduce the carriage of Salmonella among poultry, and prevent its spread to humans. In the future, Nano and his collaborators plan to develop vaccines against other bacterial pathogens that cause diseases in animals and humans. With the support of UVic Industry Partnerships, a patent application has been filed to protect this platform technology.

Explore further: Researchers annotate genome of the smallest known fungal plant pathogen

Provided by University of Victoria

4 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Discovery paves way for salmonella vaccine

Feb 13, 2012

(Medical Xpress) -- An international research team led by a University of California, Davis, immunologist has taken an important step toward an effective vaccine against salmonella, a group of increasingly antibiotic-resistant ...

Salmonella in garden birds responsive to antibiotics

Jun 02, 2008

Scientists at the University of Liverpool have found that Salmonella bacteria found in garden birds are sensitive to antibiotics, suggesting that the infection is unlike the bacteria found in livestock and humans.

Researchers use salmonella to administer vaccines

Jul 18, 2008

(PhysOrg.com) -- Researchers at the Biodesign Institute at Arizona State University have made a major step forward in their work to develop a biologically engineered organism that can effectively deliver an ...

New vaccine for hepatitis C virus

Jul 28, 2011

Murdoch University researchers have begun a study to develop a new and innovative vaccine for the hepatitis C virus (HCV).

Recommended for you

New alfalfa variety resists ravenous local pest

Apr 23, 2014

(Phys.org) —Cornell plant breeders have released a new alfalfa variety with some resistance against the alfalfa snout beetle, which has ravaged alfalfa fields in nine northern New York counties and across ...

New patenting guidelines are needed for biotechnology

Apr 22, 2014

Biotechnology scientists must be aware of the broad patent landscape and push for new patent and licensing guidelines, according to a new paper from Rice University's Baker Institute for Public Policy.

User comments : 0

More news stories

New breast cancer imaging method promising

The new PAMmography method for imaging breast cancer developed by the University of Twente's MIRA research institute and the Medisch Spectrum Twente hospital appears to be a promising new method that could ...

Research proves nanobubbles are superstable

The intense research interest in surface nanobubbles arises from their potential applications in microfluidics and the scientific challenge for controlling their fundamental physical properties. One of the ...

Using antineutrinos to monitor nuclear reactors

When monitoring nuclear reactors, the International Atomic Energy Agency has to rely on input given by the operators. In the future, antineutrino detectors may provide an additional option for monitoring. ...