Arctic evolution leads to salmonella vaccine

Mar 05, 2012

Bacteria harvested from the frigid waters of the Arctic could be the key to a new type of temperature-sensitive vaccine. University of Victoria microbiology researcher Dr. Francis Nano has received Genome BC Proof-of-Concept funding to use that bacteria to develop a vaccine that will immunize chickens against Salmonella enterica.

Vaccinating animals against a variety of diseases has begun to play an important role in ensuring global food security, especially as the overuse of has led to a rise in . infection, or salmonellosis, is one of the most common food-borne illnesses in the world. Approximately 10,000 cases of are reported by Canadians each year, and many more cases go unreported. Internationally, millions of deaths are linked to this infection.

Nano’s lab at UVic will replace an essential gene in a Salmonella bacterium with a gene from an Arctic bacterium. This process will create a modified bacterium that will no longer be able to survive in a warm environment such as the tissue of a warm-blooded animal. When used as a vaccine this temperature-sensitive bacterium will immunize and protect the recipient from future infection.

“Using Arctic genes, we can create bacterial pathogens that behave like vaccines, much like the many temperature-sensitive viruses that are used as vaccines,” says Nano. “We can apply this same approach to develop new vaccines against many diseases of humans and animals.”

Nano and his collaborators are using this technology to produce a cost-effective vaccine that will reduce the carriage of Salmonella among poultry, and prevent its spread to humans. In the future, Nano and his collaborators plan to develop vaccines against other bacterial pathogens that cause diseases in animals and humans. With the support of UVic Industry Partnerships, a patent application has been filed to protect this platform technology.

Explore further: Free the seed: OSSI nurtures growing plants without patent barriers

Provided by University of Victoria

4 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Discovery paves way for salmonella vaccine

Feb 13, 2012

(Medical Xpress) -- An international research team led by a University of California, Davis, immunologist has taken an important step toward an effective vaccine against salmonella, a group of increasingly antibiotic-resistant ...

Salmonella in garden birds responsive to antibiotics

Jun 02, 2008

Scientists at the University of Liverpool have found that Salmonella bacteria found in garden birds are sensitive to antibiotics, suggesting that the infection is unlike the bacteria found in livestock and humans.

Researchers use salmonella to administer vaccines

Jul 18, 2008

(PhysOrg.com) -- Researchers at the Biodesign Institute at Arizona State University have made a major step forward in their work to develop a biologically engineered organism that can effectively deliver an ...

New vaccine for hepatitis C virus

Jul 28, 2011

Murdoch University researchers have begun a study to develop a new and innovative vaccine for the hepatitis C virus (HCV).

Recommended for you

User comments : 0

More news stories

Researchers successfully clone adult human stem cells

(Phys.org) —An international team of researchers, led by Robert Lanza, of Advanced Cell Technology, has announced that they have performed the first successful cloning of adult human skin cells into stem ...

Biologists help solve fungi mysteries

(Phys.org) —A new genetic analysis revealing the previously unknown biodiversity and distribution of thousands of fungi in North America might also reveal a previously underappreciated contributor to climate ...

NASA's space station Robonaut finally getting legs

Robonaut, the first out-of-this-world humanoid, is finally getting its space legs. For three years, Robonaut has had to manage from the waist up. This new pair of legs means the experimental robot—now stuck ...

Ex-Apple chief plans mobile phone for India

Former Apple chief executive John Sculley, whose marketing skills helped bring the personal computer to desktops worldwide, says he plans to launch a mobile phone in India to exploit its still largely untapped ...

Filipino tests negative for Middle East virus

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

Egypt archaeologists find ancient writer's tomb

Egypt's minister of antiquities says a team of Spanish archaeologists has discovered two tombs in the southern part of the country, one of them belonging to a writer and containing a trove of artifacts including reed pens ...

Airbnb rental site raises $450 mn

Online lodging listings website Airbnb inked a $450 million funding deal with investors led by TPG, a source close to the matter said Friday.