The extracellular matrix

Dec 12, 2011
Atomic Force Microscopy (AFM) image of the designed extracellular matrix

NPL scientists have created a functional model of the native extracellular matrix which provides structural support to cells to aid growth and proliferation and could lead to advances in regenerative medicine.

The extracellular matrix (ECM) provides the physical and chemical conditions that enable the development of all . It is a complex nano-to-microscale structure made up of protein fibres and serves as a dynamic substrate that supports tissue repair and regeneration.

Man-made structures designed to mimic and replace the native matrix in damaged or diseased tissues are highly sought after to advance our understanding of tissue organisation and to make regenerative medicine a reality.

Self-assembling peptide fibres that have similar properties to those of the native matrices are of particular interest. However, these near-crystalline fail to arrange themselves into interconnected meshes at the , which is critical for bringing cells together and supporting .

To solve this problem, a research team at NPL designed a small protein consisting of two complementary domains (structural units) that promote the formation of highly branched networks of fibres that span microscopic dimensions. The team showed that the created matrix is very efficient in supporting cell attachment, growth and proliferation.

Explore further: New technique reveals immune cell motion through variety of tissues

Provided by National Physical Laboratory

4 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Hydrogels provide scaffolding for growth of bone cells

Aug 17, 2008

Hyaluronic hydrogels developed by Carnegie Mellon University researchers may provide a suitable scaffolding to enable bone regeneration. The hydrogels, created by Newell Washburn, Krzysztof Matyjaszewski and Jeffrey Hollinger, ...

Coming Soon: Blood Vessels from a Test Tube?

Jun 04, 2007

Our tissues and organs consist of a complex, closely balanced assembly of different types of cells, extracellular matrix, and special signal-carrying molecules. The growth of such structures in the laboratory, perhaps for ...

Recommended for you

'Global positioning' for molecules

19 hours ago

In everyday life, the global positioning system (GPS) can be employed to reliably determine the momentary location of one en route to the desired destination. Scientists from the Institute of Physical and ...

Cells build 'cupboards' to store metals

Dec 17, 2014

Lawrence Livermore researchers in conjunction with collaborators at University of California (link is external), Los Angeles have found that some cells build intracellular compartments that allow the cell ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.