Mice with fewer insulin-signaling receptors don't live longer

November 23, 2011

Scientists studying longevity thought it might be good to lack a copy of a gene, called IGF1 receptor, that is important in insulin signaling. Previous studies showed invertebrates that lacked the copy lived longer, even if their bodies were less responsive to insulin, the hormone that lowers blood sugar.

A new study from The University of Texas Health Science Center San Antonio challenges this. Knocking out one copy of the gene failed to increase the life span of male mice, and it only modestly increased the life span of female littermates.

Martin Adamo, Ph.D., professor of biochemistry, and Arlan Richardson, Ph.D., professor of cellular and , lead the laboratories that conducted the study. "Our data show insufficiency of this insulin-signaling gene does not produce a robust increase in as previously reported in invertebrates," Dr. Richardson said.

Dr. Adamo said: "This demonstrates that reducing insulin signaling through the IGF1 pathway in mammals does not play the same role in aging that is observed in invertebrates."

A receptor is a molecule on a cell's membrane that receives . Knocking down the genetic instructions that make IGF1 receptors results in reduced insulin signaling.

The study is described Nov. 23 in the journal .

Explore further: Researchers discover gene mutations linked to longer lifespans

Related Stories

Joslin researchers discover new effect for insulin

March 20, 2008

Researchers at the Joslin Diabetes Center have shown that insulin has a previously unknown effect that plays a role in aging and lifespan, a finding that could ultimately provide a mechanism for gene manipulations that could ...

Gene oppositely controlled by dietary protein, sugar

April 8, 2008

Researchers have discovered a gene in flies whose activity rises and falls depending upon the amount of protein and sugar in the insects’ diets. The findings, reported in the April issue of Cell Metabolism, might shed light ...

Apple peel makes mice mighty

June 7, 2011

For Popeye, spinach was the key to extra muscle. For the mice in a new University of Iowa study, it was apples, or more precisely a waxy substance called ursolic acid that's found in apple peel.

Recommended for you

Brazilian wasp venom kills cancer cells by opening them up

September 1, 2015

The social wasp Polybia paulista protects itself against predators by producing venom known to contain a powerful cancer-fighting ingredient. A Biophysical Journal study published September 1 reveals exactly how the venom's ...

Naturally-occurring protein enables slower-melting ice cream

August 31, 2015

(Phys.org)—Scientists have developed a slower-melting ice cream—consider the advantages the next time a hot summer day turns your child's cone with its dream-like mound of orange, vanilla and lemon swirls with chocolate ...

Antibody-making bacteria promise drug development

August 31, 2015

Monoclonal antibodies, proteins that bind to and destroy foreign invaders in our bodies, routinely are used as therapeutic agents to fight a wide range of maladies including breast cancer, leukemia, asthma, arthritis, psoriasis, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.