A new mechanism inhibiting the spread and growth of cancer found in motile cells

Oct 21, 2011

A revolutionary discovery regarding motile cancer cells made by research scientists at VTT Technical Research Centre of Finland and the University of Turku is challenging previous conceptions. The results have been published on July 25, 2011 in the Journal of Cell Biology, one of the most renowned journals in the field.

Finnish researchers found a new mechanism inhibiting the spread and growth of cancer found in motile cells

It has long been held that cells use different mechanisms for regulating migration and growth. This conception was proven false by research scientists Anja Mai and Stefan Veltel from the research team of Professor Johanna Ivaska. Their findings on aggressively spreading revealed – completely contrary to previous expectations – that a single cell protein (p120RasGAP) acts as an important inhibitor of both cell migration and growth.

Cancer cells are characterised by traits such as uncontrollable growth and the ability to metastasise. The findings of the research team now show that the regulation of these two deadly traits in cells is interconnected, which may be an important piece of information in the future development of medicines.

Explore further: Scientists throw light on the mechanism of plants' ticking clock

More information: Johanna Ivaska has been interviewed in the journal's podcast, which highlights a handful of leading international studies each month. The interview can be heard in the podcast archive of the journal: www.jcb.org/biobytes

Provided by VTT Technical Research Centre of Finland

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Scientists discover new information on spreading of cancer

Jun 30, 2009

A joint research group of VTT Technical Research Centre of Finland and the University of Turku, led by Professor Johanna Ivaska, has discovered a mechanism lung cancer cells use when spreading into the body to form metastases.

Red wine ingredient resveratrol stops breast cancer growth

Sep 29, 2011

Cheers! A new research report appearing in the October 2011 issue of The FASEB Journal shows that resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of est ...

Recommended for you

Fighting bacteria—with viruses

Jul 24, 2014

Research published today in PLOS Pathogens reveals how viruses called bacteriophages destroy the bacterium Clostridium difficile (C. diff), which is becoming a serious problem in hospitals and healthcare institutes, due to its re ...

Atomic structure of key muscle component revealed

Jul 24, 2014

Actin is the most abundant protein in the body, and when you look more closely at its fundamental role in life, it's easy to see why. It is the basis of most movement in the body, and all cells and components ...

Brand new technology detects probiotic organisms in food

Jul 23, 2014

In the food industr, ity is very important to ensure the quality and safety of products consumed by the population to improve their properties and reduce foodborne illness. Therefore, a team of Mexican researchers ...

Protein evolution follows a modular principle

Jul 23, 2014

Proteins impart shape and stability to cells, drive metabolic processes and transmit signals. To perform these manifold tasks, they fold into complex three-dimensional shapes. Scientists at the Max Planck ...

User comments : 0