Sex gives clues to new lung cancer treatment

Aug 23, 2011
Sex gives clues to new lung cancer treatment
PhD student Lucy Cao from the ARC Centre of Excellence for Free Radical Chemistry

Research into an enzyme that produces a hormone released after sex has inspired Australian National University chemists to create new treatments for small-cell lung cancer.

Led by Professor Chris Easton and PhD student Ms. Lucy Cao from the ARC Centre of Excellence for Free Radical Chemistry and at ANU, the team are working to reduce the number of small-cell deaths by building that target the biology underlying the disease. Their work has been published in the latest edition of The Royal Society Chemistry journal, Medicinal Chemistry Communications.

“Given that one in every 28 Australians are diagnosed with lung cancer and it is the most common cause of cancer death, there is a real need to develop new pharmaceuticals to treat this disease. Although it is still early days our results are very promising,” said Professor Easton.

The team are investigating an enzyme, known as PAM, which activates a number of important peptide hormones. These include calcitonin, which promotes cell proliferation, and oxytocin, dubbed the ‘love hormone’, as it produces feelings of contentment following orgasm. Imbalances in peptide hormones have been shown to cause inflammatory diseases, asthma, and various cancers.

“Increased levels of calcitonin are correlated with poor survival rates in small-cell lung cancer patients. So we are working to reduce the levels of calcitonin, particularly through controlling the activity of the PAM enzyme,” said Ms. Cao.

Using a novel cell culture experiment that they developed for this project, the researchers have been able to model the effect of their new chemicals on small-cell lung cancer cells.

“We were excited to find that a number of our compounds are very effective in reducing the activity of PAM and decreasing calcitonin levels,” said Professor Easton.

“As we look to take these compounds into formal clinical trials we hope to provide a sexy new drug treatment to improve and extend the lives of many lung cancer sufferers,” he added.

Explore further: Classical enzymatic theory revised by including water motions

Provided by Australian National University

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Controlling lung cancer in mice with milk thistle extract

Feb 16, 2011

(PhysOrg.com) -- Silibinin, a milk thistle extract, decreases tumor size in mice by inhibiting production of an enzyme that is overexpressed in certain types cancer, researchers at the University of Colorado Cancer Center ...

Protein KO stops tumour growth

Apr 19, 2011

(PhysOrg.com) -- Research published last week in the journal PNAS may have identified a promising new target for developing drugs against one of the most common types of lung cancer.

New aging cause revealed by test tube

Mar 22, 2011

(PhysOrg.com) -- Chemists from The Australian National University have discovered a new way that ageing-related diseases can progress, opening up new preventative and treatment possibilities for conditions ...

New lung cancer gene found

Jul 19, 2011

A major challenge for cancer biologists is figuring out which among the hundreds of genetic mutations found in a cancer cell are most important for driving the cancer’s spread.

Recommended for you

Molecules that came in handy for first life on Earth

Nov 24, 2014

For the first time, chemists have successfully produced amino acid-like molecules that all have the same 'handedness', from simple building blocks and in a single test tube. Could this be how life started. ...

Jumping hurdles in the RNA world

Nov 21, 2014

Astrobiologists have shown that the formation of RNA from prebiotic reactions may not be as problematic as scientists once thought.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.