Researchers help find natural products potential of frankia

Aug 03, 2011

Soil-dwelling bacteria of the genus Frankia have the potential to produce a multitude of natural products, including antibiotics, herbicides, pigments, anticancer agents, and other useful products, according to an article in the June 2011 issue of the journal "Applied and Environmental Microbiology." University of New Hampshire professor of microbiology and genetics Louis Tisa, a Frankia expert, contributed the genomic analysis to this study.

"We were able to use cutting-edge techniques to identify unexpected compounds in this organism, Frankia," Tisa says. The researchers, led by Bradley Moore of the Scripps Oceanographic Institute, found genetic structures in Frankia that resemble those of various valuable natural product categories that produce the majority of the natural antibiotics used as drugs.

Frankia are nitrogen-fixing bacteria that live in symbiosis with actinorhizal plants (whose ranks include beech and cherry trees); they have not previously been exploited partly because these bacteria are difficult to grow in the lab. But new make it easier to transplant genes for promising natural products from Frankia into more user-friendly host bacteria for production.

"We found something unique that nobody thought to look for in these bacteria," says Tisa, who worked with his former graduate student and current lab technician Nicholas Beauchemin, on the project.

Tisa's lab provided insight on the biology that contributed to the genome mining, a recent technique that involves searching for genetic sequences, that was critical to the results and "complementary to the far more laborious traditional natural product drug discovery that has gone unchanged for decades," Moore says.

Explore further: Bacterial immune system has a better memory than expected

Related Stories

Potential treatments from cryptic genes

Jun 02, 2008

Big pharma gave up on soil bacteria as a source of antibiotics too soon, according to research published in the June issue of Microbiology. Scientists have been mining microbial genomes for new natural products that may ha ...

New bacteria discovered in tar pits

May 17, 2007

U.S. environmental scientists have discovered the Rancho La Brea tar pits in Los Angeles contain hundreds of new species of unusual bacteria.

Recommended for you

Researchers develop new model of cellular movement

2 hours ago

(Phys.org) —Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of ...

For resetting circadian rhythms, neural cooperation is key

22 hours ago

Fruit flies are pretty predictable when it comes to scheduling their days, with peaks of activity at dawn and dusk and rest times in between. Now, researchers reporting in the Cell Press journal Cell Reports on April 17th h ...

Rapid and accurate mRNA detection in plant tissues

23 hours ago

Gene expression is the process whereby the genetic information of DNA is used to manufacture functional products, such as proteins, which have numerous different functions in living organisms. Messenger RNA (mRNA) serves ...

User comments : 0

More news stories

Researchers develop new model of cellular movement

(Phys.org) —Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of ...

Scientists tether lionfish to Cayman reefs

Research done by U.S. scientists in the Cayman Islands suggests that native predators can be trained to gobble up invasive lionfish that colonize regional reefs and voraciously prey on juvenile marine creatures.